As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Ahmed Bashir about how the bariatric community can safely resume surgery...
1. When you consider all the recommendations and best practices around the globe, what do you think is the first priority for your respective country to focus in terms of managing obese patients during & after COVID-19?
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to Michel Gagner about how the bariatric community can safely resume surgery...
1. There has been much debate surrounding the use of radiofrequency energy/ electrothermal bipolar devices versus ultrasonic coagulating devices, with regards to the possible risk of infection through aerosolization. What are your thoughts on device use and aerosolization?
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to current IFSO-EC President, Gerhard Prager about how the bariatric community can safely resume surgery...
1. Two of many key recommendations from a recent IFSO publication that you co-authored, 'How are We Going to Restart Elective Bariatric and Metabolic Surgery after the Peak of Covid-19Pandemic?’ concerned pre- and post-operative care consultations.
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to past IFSO President, Kelvin Higa about how the bariatric community can safely resume surgery...
1. What have been the most important changes you have developed at your centre to the ‘bariatric patient pathway’ to ensure the safety of both the patient and bariatric and metabolic specialists?
As bariatric and metabolic surgery restarts across the world, Bariatric News spoke to current IFSO President, Lilian Kow about how the bariatric community can safely resume surgery...
1. As the current president of IFSO, what steps has the Federation taken to help promote the safe return to surgery for patients and bariatric specialists?
The outcomes of an online survey conducted by Bariatric News has revealed that there is little consensus among bariatric and metabolic specialists around prioritising specific groups (non-diabetics, BMI, age) when bariatric surgery is resumed during the current COVID-19 pandemic. However, there was a high degree of consensus concerning testing, personnel protective equipment, who should perform surgery and utilising post-operative tele-conferencing.
Men who were overweight or had obesity as adolescents have a substantial risk increase for developing venous thromboembolism (VTE) later in life compared with those who were not overweight or had obesity when they were adolescents, according to research headed by Sahlgrenska Academy at the University of Gothenburg in Sweden.
Allurion Technologies has announced the company’s entry into Asia with the launch of the Elipse Program in Hong Kong, Malaysia, and Singapore. Building upon its success in Europe, Middle East, and Latin America, the company’s entry into Asia could impact the lives of over one billion people who are overweight or have obesity in a region that historically has had limited access to non-invasive weight loss treatments.
Internet-connected surveillance as part of a bariatric surgery enhanced recovery after surgery (ERAS) programme was safe and effective in detecting 100% of early complications and most patients were satisfied with their care, according to researchers from France. The findings were reported in the paper, ‘Connected Surveillance for Detection of Complications After Early Discharge from Bariatric Surgery’, was published in Obesity Surgery.
The British Obesity & Metabolic Surgery Society and Obesity UK have responded to the UK government’s recently announced obesity strategy to get the nation fit and healthy, protect themselves against COVID-19 and protect the NHS.
Patients with obesity are at higher risk of developing heart failure and yet, many obese patients face obstacles to getting heart transplants, as recovery is considered to be more challenging and risky in individuals with high body mass. Some physicians have attempted to pair bariatric surgery, which has shown to effectively reduce body mass in some patients, with LVAD surgery - considered a bridge to heart transplantation. However, the studies in general were too small to assess whether the approach was generalizable.
Publicly funded Roux-en-Y gastric bypass (RYGB) appeared to be higher in the first three years but similar thereafter to the costs of non-surgical interventions, according to the paper, ‘Association of Roux-en-Y Gastric Bypass With Postoperative Health Care Use and Expenditures in Canada’, published in JAMA Surgery. The study found that hospital and emergency department (ED) readmissions after surgical bariatric interventions were associated with increased health care expenditures.
The UK government has revealed a raft of measures as part of the government’s new obesity strategy to get the nation fit and healthy, protect themselves against COVID-19 and protect the NHS. Living with excess weight puts people at greater risk of serious illness or death from COVID-19, with risk growing substantially as BMI increases. Nearly 8% of critically ill patients with COVID-19 in intensive care units have been morbidly obese, compared with 2.9% of the general population.
Bariatric surgery can improve female sexual function decreasing the risk of sexual dysfunction presence and the advantages are associated with the total BMI loss, according to researchers from Medical University of Warsaw and the Military Institute of Medicine, Warsaw, Poland. The outcomes were featured in the paper, ‘The effect of bariatric surgery on female sexual function: a cross-sectional study’, published in Scientific Reports.
Lexington Medical, a US-based medical device company delivering minimally-invasive surgical stapling solutions, and BOWA Medical, a leading innovator of energy based surgery products for medical applications, have entered into a commercial agreement.
One-year outcomes from a study evaluating the RefluxStop device (Implantica) has found the device is safe and effective when treating gastroesophageal reflux disease (GERD), with no complications related to the device and complications caused by the compression of the food passageway (ie. dysphagia, odynophagia and gas bloating) are not an issue with the RefluxStop procedure. The outcomes were reported in the paper, ‘Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results’, published in BMC Surgery.
The two-year outcomes from the Tehran obesity treatment study (TOTS), which is comparing the effectiveness and safety of sleeve gastrectomy (SG) and gastric bypass (GB), has reported that both surgical procedures are effective in the control of obesity and remission of its comorbidities. However, since SG was associated with a lower rate of complications, it seems that SG should be considered as a suitable procedure for obese patients, especially those with a healthier metabolic profile, the authors report.
A review article in Therapeutic Advances in Gastroenterology describes the refinement of EsophyX technology (EndoGastric Solutions) and the evolution of transoral incisionless fundoplication (TIF) as a safe and effective treatment for patients with gastroesophageal reflux disease (GERD).
Apollo Endosurgery has submitted a 510k submission of the X-Tack Endoscopic HeliX Tacking System to the FDA seeking clearance for the new, through-the-scope, suture-based device designed specifically for closing defects in the lower gastrointestinal tract with additional applications in the upper gastrointestinal tract.
Olympus has launched the EVIS X1 endoscopy system to improve outcomes from disorders of the stomach, colon and oesophagus, as well as from bronchial diseases. EVIS X1 supports accurate screening and confident diagnosis through introducing new and easy-to-use technologies to support how gastrointestinal disorders, such as colorectal cancer (CRC), or bronchial diseases are detected, characterised and treated.
The risk of greater COVID-19 severity and death is higher in people with BMI>30 according to a study published in the European Journal of Endocrinology. The study findings showed that BMI>30 was associated with a significantly higher risk of respiratory failure, admission to intensive care and death in COVID-19 patients, regardless of age, gender and other associated diseases.
A new Northwestern Medicine remote weight-loss programme, called Opt-IN, provides maximum weight loss for the lowest cost and with much less hassle than the gold-standard National Diabetes Prevention Program (DPP), according to the outcomes from a clinical trial. The DPP is claimed to be the most successful behavioural non-drug treatment currently available. Outcomes from the Opt-IN programme show that participants in a clinical trial lose 11 to 13lbs, which is equivalent to the DPP's success rate.
Users of public insurance are paying more for bariatric surgery compared to private insurance patients, according to researchers the University of Georgia.
Prior bariatric surgery (prior-BS) in type 2 diabetes mellitus (T2DM) patients undergoing noncardiac surgery is associated with a lower risk of major adverse cardiovascular and cerebrovascular events (MACCEs), according to researchers from The First Affiliated Hospital, Sun Yat-Sen University, South China University of Technology, Guangzhou and the Second Military Medical University, Shanghai, China.
IFSO Endoscopy Committee has published a Position Statement on the best practise of bariatric endoscopy in response to the CVOID-19 pandemic. The statement offers guidance on navigating bariatric endoscopic procedures in patients with obesity during the COVID-19 pandemic, in the hope of mitigating the risk of SARS-CoV-2 transmission to vulnerable patients and healthcare workers. The statement acknowledges that the recommendations may evolve as the pandemic progresses.
African American (AA) patients undergoing bariatric surgery are younger and heavier than non-AA patients, present with different comorbidity profiles and exhibit worse outcomes following Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) than non-AA patients, including increased mortality rates in AA-SG patients.
Breast cancer patients who are overweight or have obesity might benefit less from treatment with docetaxel, a common chemotherapy drug, than lean patients, according to an international team of researchers who carried out a retrospective analysis of data from a large clinical trial.
A team of Australian paediatric specialists, including an expert from the University of Adelaide, has produced new guidelines regarding assessment and management of type 2 diabetes (T2D) in Australian and New Zealand children and adolescents. With the incidence of T2D on the rise among children and adolescents, especially in Indigenous communities, early assessment and management is critical.
A new guideline from the Canadian Task Force on Preventive Health Care, based on a rigorous systematic review of the latest evidence, found no benefit of routine screening for oesophageal adenocarcinoma (EAC) and precursor conditions (Barrett oesophagus and dysplasia) in patients with chronic gastroesophageal reflux disease (GERD).
People among black and minority ethnic communities (BME) who have obesity are around two times higher the risk of contracting COVID-19 compared to white Europeans, according to a study conducted by a team of Leicester researchers.
Researchers at Yale have identified a molecule that plays a key role in the body's inflammatory response to overeating, which can lead to obesity, diabetes and other metabolic diseases. The finding suggests that the molecule could be a promising therapeutic target to control this inflammation and keep metabolic diseases in check. The study, ‘OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance’, was publishing in the Proceedings of the National Academy of Sciences.
Researchers from Osaka University, Japan, have developed a novel vaccine that removes aged immune cells and then demonstrated an improvement of diabetes-associated metabolic derangements by vaccinating mice with obesity. The study, 'The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice', was published in Nature Communications.
Researchers from Obesity Center Máxima, Máxima Medical Center, Department of Surgery, Eindhoven/Veldhoven, in the Netherlands, have initiated the ‘Banded Roux-en-Y gastric bypass in patients with superobesity (BRandY-study)’ to assess the added value of the banded Roux-en-Y gastric bypass in patients with super-obesity (BMI>50) on long-term weight loss outcomes.
One of the first studies to define and examine the perceptions ‘bariatric families’ towards obesity has reported that there are significant differences between the perceptions of those parents and children – in a ‘bariatric family’ - toward themselves, their health and the preferred mode of obesity treatment, compared to non-bariatric families, according to researchers from Dana Dwek Children’s Hospital and Tel Aviv University, Tel Aviv, Israel.
Researchers from Europe have initiated the first randomised controlled trial that will compare sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) in adolescents with severe obesity. The TEEN-BEST trial is designed to determine whether SG is non-inferior to RYGB in terms of total body weight (TBW) loss.
An international team of bariatric and metabolic surgery (B&M) experts has published a series of protocols designed to assist B&M surgeons and Allied Healthcare Professionals when restarting elective B&M surgery following the outbreak of COVID-19, based on experts’ opinions, reviews of small series and publications from previous different viral epidemic outbreaks.
Type 2 diabetes can be reversed in more than 60% of participants through dietary change, physical activity and behaviour change, and without medication or bariatric surgery, according to a team of researchers from Qatar. These were the conclusions from the DIADEM-I clinical trial, thought to be the first intensive lifestyle intervention trial in the Middle East and North Africa region and is the country’s first clinical trial in primary care.
Obesity is associated with a higher risk of dementia up to 15 years later, according to a study by researchers from University College London, London, UK, suggesting that weight management could play a significant role in reducing the risk of dementia. These findings have significant implications for dementia prevention and overall public health.
The FDA has approved the expansion of a US- pilot study of the USGI Medical’s non-invasive, endoscopic procedure, known as POSE2.0. The study is designed to evaluate weight loss for adults suffering from obesity with a BMI35-40 and obesity-related comorbidities, such as diabetes or hypertension. The FDA approval, based on the promising results obtained so far from the first stage of the study, means the pilot study will be expanded to four US institutions and 35 US subjects.
Gelesis, who recently received European approval for its PLENITY weight loss treatment, has entered into a partnership with China Medical System Holdings Limited (CMS) for the commercialisation of Plenity in China. The partnership will build on Gelesis’ commitment to providing patient-initiated care for adults with overweight and obesity that augments traditional healthcare provider services with digital access to care.
Bariatric surgery may decrease overall cancer risk in women, but not men, within the first five years after surgery, and according to the study’s researchers the decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.
ReShape Lifesciences has entered into a partnership with inHealth Lifestyle Therapeutics (formerly inHealth Medical Services), a Lifestyle Therapeutics company, to launch the ReShapeCare virtual health coaching programme in June 2020. The service is tailored for patients having treatment for their obesity, those who may have lost continuity of care and patients pursuing weight loss surgery and medically supervised weight loss programmes.
The American Society for Metabolic and Bariatric Surgery (ASMBS) has declared metabolic and bariatric surgery "medically necessary and the best treatment for those with the life-threatening and life-limiting disease of severe obesity" and called for the safe and rapid resumption of procedures, which have been largely postponed along with other surgeries deemed elective amid the COVID-19 pandemic.
Researchers from Eindhoven University of Technology, The Netherlands, are working on mathematical models that show the human metabolism for each person. The DigiTwin research project, led by Natal van Riel, aims to build a digital copy of individual patients to predict the success and to determine the necessary aftercare of a treatment such as gastric bypass surgery in patients with obesity.
The Intellectual Property Office has granted Benmor Medical patent no. EP3315107 on the Aurum+ Bariatric Bed, entitled: ‘Barrier for a Bed’ in the UK and Europe. This decision adds to the company’s patent portfolio for the features on its innovative Deprimo Floor Level Bed.
Novo Nordisk has announced the headline results from two clinical trials with a novel once-weekly subcutaneous amylin analogue (AM833), a phase 2 monotherapy trial and a phase 1 combination trial of AM833 and once-weekly subcutaneous semaglutide 2.4mg.
From 13-14 June 2020, the First International Conference “Controversies in bariatric surgery” (CIBS 2020) was held in St Petersburg, Russia, and due to the COVID-19 pandemic was implemented in an innovative online format, organised by the Society of Bariatric Surgeons of Russia, with the support of IFSO, together with the company Uniclinic.
Gelesis, a biotechnology company developing a novel hydrogel platform technology to treat obesity and other chronic diseases related to the gastrointestinal (GI) tract, has received approval to market Plenity, a novel weight loss treatment, in Europe. Gelesis received a Conformité Européenne (CE) mark for Plenity as a class III medical device indicated for weight loss in overweight and obese adults with a BMI25-40, when used in conjunction with diet and exercise.
Researchers from Iran performing laparoscopic mini-gastric bypass/one anastomosis gastric bypass (MGB/OAGB) have reported that 180cm intestinal bypassed length works for patients with a BMI40–45 and 45–50 with significant decreases in weight and BMI, and improvements in glycolipid profiles.
One anastomosis gastric bypass (OAGB-MGB) has a less steep learning curve compared to Roux-en Y gastric bypass (RYGB), according to researchers Fang Hospital, Taipei Medical University, Taipei City, Taiwan. The study also reported that the proficiency acquired can be transferred to subsequent practice for RYGB in terms of acceptable operation time and length of stay without an increase in complications.
A study investigating the prevalence and analysing the role of fascia closure in the development of trocar hernias has reported that trocar site hernias are an underestimated complication of minimally invasive, multi-portal bariatric surgery, and the prevalence of asymptomatic hernias is probably higher than initially expected. The study also found that fascia closure did not protect against trocar hernias.
If a child is infected with the new coronavirus, having obesity appears to greatly raise the odds for developing a severe form of COVID-19, according to a report was based on 50 cases of paediatric COVID-19 severe enough to require admission to a New York City hospital.
Routine post-sleeve gastrectomy gastrografin (RSG) to detect post- laparoscopic sleeve gastrectomy (LSG) complications, especially leaks, is needless and unnecessarily increases the overall costs as it makes no difference in detecting leaks, according to researchers from Saudi Arabia.
A letter published in the New England Journal of Medicine, and signed by an international group of 17 leading diabetes experts from the multidisciplinary Diabetes Surgery Summit (DSS), has announced the creation of the CoviDiab project. The CoviDiab project is a collaborative international research initiative that has established a Global Registry to collect new cases of diabetes in patients with COVID-19.
Bariatric News is carrying out a survey of Bariatric and Metabolic Surgeons and Allied Healthcare Professionals to collect and report their views on safely returning to bariatric surgery post COVID-19.
The survey is anonymous and only takes 2 minutes (13 questions) to complete. The outcomes will be published on www.bariatricnews.net in the coming weeks.
Please click here to access the survey.
Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut.
Cells in the lining of the small intestine are replaced around every five days, the quickest rate for any organ in the body. This fast replacement helps the lining cope with the damage it suffers as a result of breaking down food and absorbing nutrients.
Researchers from the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, investigating the effect of a Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans, have reported that increased markers are not a sign of pancreatitis, but that GLP‐1RAs is creating a new normal state, a so-called new steady state, in the patients.
Roux-en-Y gastric bypass surgery (RYGB) is more effective than best medical treatment (BMT) for achieving remission of albuminuria and stage G1 to G3 and A2 to A3 CKD in patients with type 2 diabetes and obesity at 24 months, according to the results of a randomised clinical trial by researchers from Brazil.
Body mass index is likely to be an inconsistent measure of obesity in Māori and Pacific patients, according to a study by University of Otago researchers. Specifically, researchers from HeartOtago - a group of cardiovascular researchers and clinicians located at the University and Dunedin Hospital - looked at epicardial adipose tissue (EAT), a special form of fat surrounding the heart which has been linked to increased risk of heart attacks and disturbances in heart rhythm.
Sleeve gastrectomy (SG) might be the best option for weight loss in patients in whom fractures could be a concern, compared with Roux-en-Y Gastric Bypass (RYGB) which maybe be associated with an increased fracture risk, according to researchers from Rush University Medical Center, Chicago, IL.
Participants had a wide range of metabolic responses after eating in apparently healthy adults and that inflammation triggered by the food they consumed varied up to ten-fold, according to researchers led by King's College London after they published the first published results from PREDICT, the largest ongoing nutritional study of its kind. The results were featured in the paper, ‘Human postprandial responses to food and potential for precision nutrition’, published in Nature Medicine and presented at the American Society of Nutrition 2020.
Researchers have identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.
The COVID-19 pandemic is having a significant impact on people with obesity as they struggle to manage their weight and mental health during shelter-in-place orders, according to research led by The University of Texas Health Science Center at Houston (UTHealth) and UT Southwestern.
In the largest study of the genetics of childhood obesity, researchers have looked at why some children gain weight very easily and have identified three genes that might be playing an important role in controlling a person's weight.
Scientists at Cincinnati Children's and the University of Cincinnati College of Medicine have outlined the details of new cellular process that shows how adipocytes’ (fat calls) immune response worsens obesity. The team reports that type I interferons, a class of substances produced by immune cells also are produced by fat cells called adipocytes. These interferons drive a constant low-level, chronic immune response that amplifies "vigour” to a cycle of inflammation within white adipose tissue (WAT).
United Imaging has received FDA clearance of the uMR OMEGA magnetic resonance imaging (MRI) scanner, the world’s first ultra-wide 75-cm bore. With the widest bore in the market at any field strength, uMR OMEGA provides a unique, patient-centric experience designed to accommodate a wide range of patients. With a 75-cm bore and 680lbs table capacity, uMR OMEGA addresses evolving demographics in the US community, not only improving patient comfort for all but creating, for the first time, an MRI for bariatric patients.
Investigators at Flinders University have found that the nutrient sensing capacity of Enterochromaffin (EC) cells, which line the gastrointestinal tract and are the source of almost all serotonin in the body, change in mice under the influence of high-fat diet-induced obesity and metabolic disease.
Surgeons at UT Southwestern Medical Center have pioneered a new technique that prevents nipple discoloration and preserves shape in men who undergo breast reduction surgery following significant weight loss. The procedure, described in the paper, ‘An Alternative Treatment of Pseudogynecomastia in Male Patients After Massive Weight Loss’, was published in the Aesthetic Surgery Journal Open Forum.
Less family discouragement and better family communication is associated with a higher likelihood to eat evening family meals and family breakfasts together, and not in front of a television, according to the paper, ‘Family Meal Practices and Weight Talk Between Adult Weight Management and Weight Loss Surgery Patients and Their Children’, published in the Journal of Nutrition Education and Behavior.
Novo Nordisk has announced headline results from Semaglutide Treatment Effect in People with obesity (STEP) 1, a phase 3a trial in the STEP programme, which revealed the study met both primary endpoints. STEP 1 is a 68-week randomised, double-blind, multicentre, placebo-controlled weight management trial.
Fractyl Laboratories has received approval from the FDA of an Investigational Device Exemption (IDE) to begin a pivotal study of Revita DMR in type 2 diabetes (T2D) patients treated with insulin. This landmark pivotal study, called Revita T2Di, is a prospective, randomised, double-blind, sham-controlled study enrolling 300 patients at up to 35 sites around the world, with approximately 25 sites in the US.
Laparoscopic banded sleeve gastrectomy (LBSG) appears to be significantly more effective than laparoscopic sleeve gastrectomy (LSG) in terms of weight loss in the midterm follow-up, according to researchers from Italy. The randomised study, ‘Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study’, published in the Journal of Obesity, sought to compare LBSG and LSG over a four-year follow-up.
Ethicon has announced its continued support of guidelines from the Society for American Gastrointestinal and Endoscopic Surgeons (SAGES), which recommends the use of personal protective equipment (PPE) and smoke evacuation in the operating room during laparoscopic and open surgery.
Xeris Pharmaceuticals has announced positive findings from the outpatient stage of a Phase 2 proof-of-concept study of its developmental ready-to-use (RTU) glucagon in patients who experience postprandial hypoglycaemic episodes following bariatric surgery.
Researchers from the University of British Columbia, Canada, believe they have identified a gene that may prevent weight gain, after using a genetic database of more than 47,000 people in Estonia. The gene is linked to thinness and may play a role in resisting weight gain in these metabolically healthy thin people. Deleting the gene resulted in thinner flies and mice, and that the expression of it in the brain may be involved in regulating energy expenditure.
Boston University School of Medicine researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery. The retrospective study paper, 'The Mitigating Effect of Phentermine and Topiramate on Weight Regain after Roux-en-Y Gastric Bypass Surgery', was published in Obesity.
The British Obesity and Metabolic Surgery Society (BOMSS) has written a letter to British Prime Minister, Boris Johnson, welcoming his plans to launch an anti-obesity strategy and urging him to take urgent action to help the NHS to rapidly introduce effective treatment for people with severe obesity.
Post-bariatric surgical guidelines focus on a range of follow-up protocols that record and follow a patient’s glycaemic control, blood lipid profile, obstructive sleep apnoea, gastroesophageal reflux disease, body weight, etc.
Baxter International will provide financing for a grant-funded fellowship coordinated in conjunction with the European Society for Clinical Nutrition and Metabolism (ESPEN), which will significantly contribute to the ESPEN Fellowship Grants initiative and increase the number of early-career researchers awarded, allowing to fund and develop more original research in topics related to nutrition and metabolism.
Preoperative weight loss, even at a moderate degree (ie >0% to <5%), is associated with lower risk of 30-day mortality following bariatric surgery, according to a study involving nearly half a million patients by researchers from University of Iowa College of Public Health, the University of Iowa, Iowa City, and Renmin Hospital of Wuhan University, Wuhan, China.
Allurion is supporting customers around the world during COVID-19 with an expanded digital offering, in response to recent data that indicates that individuals with obesity are at higher risk of poorer outcomes from COVID-19 and that quarantine measures may lead to weight gain. The company has expanded access to telenutrition for both existing and new patients and providers, and enhanced its proprietary program to include at-home fitness, mental health and nutritional content.
Researchers from the Hubrecht Institute and Utrecht University have generated an in-depth description of the human hormone-producing cells of the gut in a large collaborative effort with other research teams. In the study, ‘High Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells’, published in the journal Cell, the researchers developed an extensive toolbox to study human hormone-producing cells in tiny versions of the gut grown in the lab called organoids.
Analysis of data from 147 countries has uncovered new insights into the positive relationship between national income and obesity rates, according to researchers from State University of New York at Buffalo. The study, ‘The association between national income and adult obesity prevalence: Empirical insights into temporal patterns and moderators of the association using 40 years of data across 147 countries’, was published in PLoS ONE.
Researchers from Trinity College Dublin are calling on the government in Ireland to change recommendations for vitamin D supplements after publishing data that highlights the association between vitamin D levels and mortality from COVID-19.
An international team of experts has issued a guidance paper that identifies patients with the greatest need for bariatric and metabolic surgery, as experts warn delaying treatment could put them at a greater risk of complications from their disease, as well as from COVID-19.
Scientists from the University of Gothenburg, Sweden, have found a new method of reducing human body weight and fat mass using weighted vests. The outcomes from the study indicate that there is something comparable to built-in bathroom scales that contributes to keeping body weight and, by the same token, fat mass constant.
Men who had obesity in their late teens are more at risk of venous thromboembolism (VTE) in the leg or lung in adult life, according to a study from the University of Gothenburg study. The risk rises successively and is highest in those who had severe obesity in adolescence. The outcomes were reported in the paper, 'Obesity in adolescent men increases the risk of venous thromboembolism in adult life', published in the Journal of Internal Medicine.
Despite overall increases in insurance coverage for low-income individuals in Medicaid expansion states, some gaps remain for individuals who have obesity, according to a recent study by a team of researchers at the University of Georgia.
UK research has found that being male or having obesity reduces chance of survival from COVID-19.
In a recent study, ‘Banding the Pouch with a Non-adjustable Ring as Revisional Procedure in Patients with Insufficient Results After Roux-en-Y Gastric Bypass: Short-term Outcomes of a Multicenter Cohort Study’, published in Obesity Surgery, researchers from The Netherlands reported the outcomes from the first multi-centre revisional banded bypass procedure in a relatively high number of patients.
The FDA has provided an update on the potential risks of over-inflation (spontaneous hyperinflation - the spontaneous filling of intragastric balloons with additional air or liquid while inside a patient’s stomach, typically resulting in the need for early device removal), acute pancreatitis and deaths in patients with Orbera and ReShape liquid-filled intragastric balloons used for weight loss in adult patients with obesity.
On Thursday, 30th April 2020, from 18:00 – 20:00 (Central European Time), BARIAlink will host the 35th BARIAlink Academy Virtual Classroom, with the aim of improving the knowledge and skills of bariatric and metabolic specialists to deal with complex cases. This latest online virtual classroom will consist of a series of presentations, discussions and polls, and will feature a special topic on ‘Visceral obesity: impact on COVID-19 pneumonia’, by Prof Dr Jan Mulier (AZ Sint Jan Brugge, Belgium).
In April 2019, Drs Michel Gagner (Hopital du Sacré Coeur, Montréal, the Westmount Square Surgical Center, Westmount, QC, Canada and the Herbert Wertheim School of Medicine, Florida International University, Miami, USA) and Paul Kemmeter (Mercy Health Saint Mary’s, Grand Rapids, MI, USA) published a systematic review comparing staple-line leak rates in five reinforcement options following laparoscopic sleeve gastrectomy (LSG) in the journal Surgical Endoscopy1.
An international review has reported that elderly people with diabetes who contract COVID-19 are at a much higher risk of dying from the disease and the virus may actually trigger the onset of diabetes in normally healthy people. Authored by an international panel of experts in the field of diabetes, they came together to provide guidance and practical recommendations for the management of diabetes for clinicians in both developed and developing countries.
Researchers at the Max Planck Institute for Metabolism Research in Cologne, Germany, have discovered that a group of nerve cells in the brains of mice promotes the consumption of high-fat food. If these so-called nociceptin neurons in the hypothalamus are activated, the animals start to eat more. The findings, ‘PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding’, were published in the journal Neuron.
Adolescent obesity is a serious and growing public health problem that threatens both current and future health outcomes, according to an editorial by Drs Leonard H Epstein (SUNY Distinguished Professor and Division Chief of Behavioral Medicine in the Department of Pediatrics in the Jacobs School of Medicine and Biomedical Sciences at University at Buffalo (UB)) and Teresa Quattrin (a UB Distinguished Professor and senior associate dean for research integration in the Jacobs School).
A study led by Yale Cancer Center (YCC) researchers has demonstrated in mice that hormones released from the pancreas itself can advance pancreatic cancer and that weight loss can stop this process in its early stages. Pancreatic cancer is expected to become the second-deadliest cancer in the US by 2030, driven in part by rising obesity rates. The research, ‘Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma’, was published in the journal Cell.
A meta-analysis designed to determine the hierarchies of different bariatric surgeries in patients with obesity and type 2 diabetes mellitus (T2DM), has reported that one anastomosis (mini) gastric bypass (OAGB/MGB) is more likely to achieve diabetes remission compared with other bariatric surgeries. However, biliopancreatic diversion without duodenal switch (BPD) appears to be the most effective surgery for achieving long‐term diabetes remission.
The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) continues to provide recommendations and information regarding surgical response to the COVID19 crisis, which are intended to provide surgeons with additional information to help manage surgical patients during the COVID-19 pandemic. They are not formal guidelines and, due to time constraints, SAGES has not reviewed them by utilising its standard rigorous guidelines process.
Obesity increases the risk of developing type 2 diabetes mellitus (T2DM) by at least six times, regardless of genetic predisposition to the disease, according to research, ‘Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study’, published in Diabetologia (the journal of the European Association for the Study of Diabetes, EASD).
Individuals with diabetes are at increased risk for bacterial, parasitic and viral infections, according to a study, ‘Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications’, published Endocrine Reviews, and demonstrates how intersections of the coronavirus infection (COVID-19) and type 2 diabetes may require new approaches in treatment for hospitalised patients.
The International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) has issued recommendations to its global healthcare providers aimed at keeping all metabolic and bariatric surgery patients and practice staff in a safe as environment as possible.
Younger people with obesity are at higher risk of developing severe COVID-19 symptoms, according to two studies published in the journals Clinical Infectious Diseases and medRxiv, which highlight that inflammation throughout the body associated with obesity could be a powerful factor in the severity of COVID-19 and could be even more significant than heart or lung disease.
A UCLA study conducted with mice has found that a gene called reprimo, which is expressed by certain neurons in the brain, may play a role in menopause-related weight gain, a phenomenon not linked to increased eating. Their findings were featured in the paper, ‘Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure’, published in Nature Metabolism.
Apollo Endosurgery has announced that the FDA has completed the review of the final Post-Approval Study (PAS) Report for the ORBERA Intragastric Balloon System and accepted that all post-approval study requirements have been fulfilled. The ORBERA Post Approval Study was a requirement following the US FDA's approval of ORBERA in August of 2015. The study was a multi-centre, open label, prospective study with a primary safety endpoint and its secondary endpoint being effectiveness. All study endpoints were successfully met.
Researchers from in the Department of Microbiology and Immunology and UofL Health, James Graham Brown Cancer Center at the University of Louisville, have published an article which proposes a unique theory that a protein secreted by fat cells drives the development of breast cancer.
The behaviour of previous coronaviruses together with physiological characteristics of diabetes may help explain why people with diabetes have a higher risk of developing COVID-19, a respiratory disease caused by the novel coronavirus SARS-CoV-2, according to a paper, ‘COVID-19 Pandemic, Corona Viruses, and Diabetes Mellitus’, published in the American Journal of Physiology-Endocrinology and Metabolism.
Enara Health, a developer of a technology-powered personalised weight loss programme, is expanding telehealth availability of its programme to all residents in California, Texas and Illinois. This rollout represents an earlier-than-planned first stage of a US rollout of the Enara Health platform, a clinical weight loss programme that takes a multi-faceted approach to obesity treatment.
Twenty-nine leading international partners have joined forces to establish a research consortium Stratification of Obese Phenotypes to Optimize Future Obesity Therapy (SOPHIA) with the aim of improving risk assessment of comorbidities and treatment for people with obesity. Obesity complications are common, but predicting who will develop any of the 200 known complications of obesity is extremely difficult. Moreover, there are insufficient predictors for who will respond to obesity treatments.
The childhood obesity rate may increase 2.4% or 1.27 million children if school closures to prevent the spread of the coronavirus continue into December, according to the study, ‘Projecting the impact of COVID-19 pandemic on childhood obesity in the U.S.: A microsimulation model’, published in the Journal of Sport and Health Science.
Researchers from the Open University of Catalonia and the Universitat Pompeu Fabra Department of Communication, Barcelona, Spain respectively, have performed a study based on the assumption that advertising is one of the factors that contributes to the obesogenic environment.