Fractyl Laboratories has received approval from the FDA of an Investigational Device Exemption (IDE) to begin a pivotal study of Revita DMR in type 2 diabetes (T2D) patients treated with insulin. This landmark pivotal study, called Revita T2Di, is a prospective, randomised, double-blind, sham-controlled study enrolling 300 patients at up to 35 sites around the world, with approximately 25 sites in the US.
Laparoscopic banded sleeve gastrectomy (LBSG) appears to be significantly more effective than laparoscopic sleeve gastrectomy (LSG) in terms of weight loss in the midterm follow-up, according to researchers from Italy. The randomised study, ‘Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study’, published in the Journal of Obesity, sought to compare LBSG and LSG over a four-year follow-up.
Ethicon has announced its continued support of guidelines from the Society for American Gastrointestinal and Endoscopic Surgeons (SAGES), which recommends the use of personal protective equipment (PPE) and smoke evacuation in the operating room during laparoscopic and open surgery.
The childhood obesity rate may increase 2.4% or 1.27 million children if school closures to prevent the spread of the coronavirus continue into December, according to the study, ‘Projecting the impact of COVID-19 pandemic on childhood obesity in the U.S.: A microsimulation model’, published in the Journal of Sport and Health Science.
Researchers from the Open University of Catalonia and the Universitat Pompeu Fabra Department of Communication, Barcelona, Spain respectively, have performed a study based on the assumption that advertising is one of the factors that contributes to the obesogenic environment.
Xeris Pharmaceuticals has announced positive findings from the outpatient stage of a Phase 2 proof-of-concept study of its developmental ready-to-use (RTU) glucagon in patients who experience postprandial hypoglycaemic episodes following bariatric surgery.
Researchers from the University of British Columbia, Canada, believe they have identified a gene that may prevent weight gain, after using a genetic database of more than 47,000 people in Estonia. The gene is linked to thinness and may play a role in resisting weight gain in these metabolically healthy thin people. Deleting the gene resulted in thinner flies and mice, and that the expression of it in the brain may be involved in regulating energy expenditure.
Boston University School of Medicine researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery. The retrospective study paper, 'The Mitigating Effect of Phentermine and Topiramate on Weight Regain after Roux-en-Y Gastric Bypass Surgery', was published in Obesity.
The British Obesity and Metabolic Surgery Society (BOMSS) has written a letter to British Prime Minister, Boris Johnson, welcoming his plans to launch an anti-obesity strategy and urging him to take urgent action to help the NHS to rapidly introduce effective treatment for people with severe obesity.
Post-bariatric surgical guidelines focus on a range of follow-up protocols that record and follow a patient’s glycaemic control, blood lipid profile, obstructive sleep apnoea, gastroesophageal reflux disease, body weight, etc.
Baxter International will provide financing for a grant-funded fellowship coordinated in conjunction with the European Society for Clinical Nutrition and Metabolism (ESPEN), which will significantly contribute to the ESPEN Fellowship Grants initiative and increase the number of early-career researchers awarded, allowing to fund and develop more original research in topics related to nutrition and metabolism.
Preoperative weight loss, even at a moderate degree (ie >0% to <5%), is associated with lower risk of 30-day mortality following bariatric surgery, according to a study involving nearly half a million patients by researchers from University of Iowa College of Public Health, the University of Iowa, Iowa City, and Renmin Hospital of Wuhan University, Wuhan, China.
Allurion is supporting customers around the world during COVID-19 with an expanded digital offering, in response to recent data that indicates that individuals with obesity are at higher risk of poorer outcomes from COVID-19 and that quarantine measures may lead to weight gain. The company has expanded access to telenutrition for both existing and new patients and providers, and enhanced its proprietary program to include at-home fitness, mental health and nutritional content.
Researchers from the Hubrecht Institute and Utrecht University have generated an in-depth description of the human hormone-producing cells of the gut in a large collaborative effort with other research teams. In the study, ‘High Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells’, published in the journal Cell, the researchers developed an extensive toolbox to study human hormone-producing cells in tiny versions of the gut grown in the lab called organoids.
Analysis of data from 147 countries has uncovered new insights into the positive relationship between national income and obesity rates, according to researchers from State University of New York at Buffalo. The study, ‘The association between national income and adult obesity prevalence: Empirical insights into temporal patterns and moderators of the association using 40 years of data across 147 countries’, was published in PLoS ONE.
Researchers from Trinity College Dublin are calling on the government in Ireland to change recommendations for vitamin D supplements after publishing data that highlights the association between vitamin D levels and mortality from COVID-19.
An international team of experts has issued a guidance paper that identifies patients with the greatest need for bariatric and metabolic surgery, as experts warn delaying treatment could put them at a greater risk of complications from their disease, as well as from COVID-19.
Scientists from the University of Gothenburg, Sweden, have found a new method of reducing human body weight and fat mass using weighted vests. The outcomes from the study indicate that there is something comparable to built-in bathroom scales that contributes to keeping body weight and, by the same token, fat mass constant.
Men who had obesity in their late teens are more at risk of venous thromboembolism (VTE) in the leg or lung in adult life, according to a study from the University of Gothenburg study. The risk rises successively and is highest in those who had severe obesity in adolescence. The outcomes were reported in the paper, 'Obesity in adolescent men increases the risk of venous thromboembolism in adult life', published in the Journal of Internal Medicine.
Despite overall increases in insurance coverage for low-income individuals in Medicaid expansion states, some gaps remain for individuals who have obesity, according to a recent study by a team of researchers at the University of Georgia.
