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Benefits of metformin go beyond for Type 2 diabetes

Metformin, one of the most widely used medications in the world and is commonly prescribed for Type 2 diabetes, however in preclinical models, metformin also showed benefits on aging and a number of diverse diseases such as cognitive disorders, cancer and cardiovascular disease. Until now, the mechanisms were not fully understood, but researchers at McMaster University have unlocked one of the secrets behind the many benefits of metformin.

Cancer risk increases for individuals who are overweight before 40

The risk of cancer increases considerably if a person gains weight before the age of 40 with the risk of endometrial cancer increasing by 70 percent, according to an international study, headed by researchers from University of Bergen, Norway.

“Obesity is an established risk factor for several cancers,” said Professor Tone Bjørge, University of Bergen. “In this study, we have focused on the degree, timing and duration of overweight and obesity in relation to cancer risk.”

French researchers report sugary drinks linked to cancer

French researchers have found that drinking only a small glass of sugary drink per day could lead to an 18 percent increase in the risk of cancer and a 22 percent increase in breast cancers. The investigators noted that sugary drinks are being consumed increasingly and this is raising the disease burden. Sugary drinks are associated with obesity and related problems. Earlier studies have connected sugary drinks to heart disease and diabetes.

People with obesity outnumber smokers two to one

New figures from Cancer Research UK show that people who have obesity now outnumber people who smoke two to one in the UK and excess weight causes more cases of certain cancers than smoking, as the charity urges Government action to tackle obesity. Almost a third of UK adults have obesity and, while smoking is still the nation’s biggest preventable cause of cancer and carries a much higher risk of the disease than obesity, Cancer Research UK’s analysis revealed that being overweight or obese trumps smoking as the leading cause of four different types of cancer.

Bariatric surgery reduces the development of colorectal lesions

Bariatric surgery was associated with fewer incidences of new colorectal lesions in patients undergoing bariatric surgery compared with a control group not undergoing bariatric surgery, according to researchers from University of Virginia, Charlottesville, VA.

Lifestyle risk factors account for 27% of all cancer cases in Brazil

Lifestyle risk factors such as smoking, alcohol consumption, overweight and obesity, unhealthy diet and lack of physical activity are associated with a third of all deaths caused by 20 types of cancer in Brazil, according to an epidemiological study. The study shows that lifestyle risk factors account for 114,497 annual cases of cancer in Brazil, which represents 27% of all cancer cases, and 63,000 deaths, or 34% of cancer mortality.

Studies explore mechanisms behind obesity-cancer link

New studies led by University of North Carolina Lineberger Comprehensive Cancer Center researchers are exploring the biological mechanisms behind obesity and its link with cancer. Research findings presented at the American Association for Cancer Research Annual Meeting 2019 have revealed possible reasons for obesity-related resistance to breast cancer treatment and possible strategies to overcome obesity-related immune suppression in cancer.

Obesity-linked cancers on the rise in young adults

A sharp increase in obesity-linked cancers among young adults in the US could foreshadow a reversal in the overall decline in cancer mortality. In a sweeping study covering two-thirds of the US population, researchers from the American Cancer Society, showed that half a dozen cancers for which obesity is a known risk factor became more frequent from 1995 to 2015 among women and men under 50. The younger the age bracket, the more quickly these cancers gained ground,

Excess body weight responsible for four percent of cancers

Policies, economic systems, and marketing practices that promote the consumption of energy-dense, nutrient-poor food, changing behavioural patterns that couple high total energy intake with insufficient physical activity, and human-built environments that amplify these factors are driving a worldwide rise in excess body weight, according to a report.

Immune surveillance systems link between obesity and cancer

Scientists have made a major discovery that shines a new, explanatory light on the link between obesity and cancer. Their research confirms why the body's immune surveillance systems - led by cancer-fighting Natural Killer cells - stutter and fail in the presence of excess fat. Additionally, it outlines possible paths to new treatment strategies that would see ‘fat-clogged’ Natural Killer cells molecularly re-programmed and jolted back into action.

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