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Metformin may help patients maintain weight loss long-term

In the Diabetes Prevention Program (DPP) clinical trial and its long-term follow-up study, among the persons who lost at least 5 percent of their body weight during the first year, long-term maintenance of weight loss was more likely if they had been assigned to treatment with metformin than with placebo or lifestyle intervention. Being older and losing a greater amount of weight in the first year were the most consistent predictors of lasting weight loss.

Gastric banding more effective than metformin in treating T2DM

People with prediabetes or new-onset type 2 diabetes who had gastric banding had similar stabilisation of their disease to those who took metformin alone, according to a study supported by the National Institutes of Health.

Two T2DM medications do not slow progression in youths

In young patients with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to a study presented at the American Diabetes Association Scientific Sessions in Orlando, FL, and published in Diabetes Care.

Intensive glucose control for T2DM can increase the risk of mortality

The common approach of intensive glucose control to achieve low blood sugar targets in type 2 diabetes can increase the risk of mortality, according to a study by researchers from Cardiff University, UK. The findings of the study also suggest that neither randomised trials nor observational studies have been able to demonstrate a consistent pattern of association between levels of glucose control and adverse outcome, without any explanation as to why.

Intensive medical treatment reverses type 2 diabetes

Type 2 diabetes can be reversed with intensive medical treatment using oral medications, insulin and lifestyle therapies, according to a small study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. The study researchers reported that short course of intensive lifestyle and drug therapy achieves on-treatment normoglycemia and promotes sustained weight loss. It may also achieve prolonged, drug-free diabetes remission and strongly supports ongoing studies of novel medical regimens targeting remission.

ACP provides updates recommendations for T2DM

Physicians should prescribe metformin to patients with type 2 diabetes when medication is needed to improve high blood sugar, the American College of Physicians (ACP) recommends in an evidence-based clinical practice guideline published in Annals of Internal Medicine. The American Academy of Family Physicians has also endorsed the guideline.

Lifestyle interventions most cost-effective approach

Behavioural and drug interventions aiming to prevent people with prediabetes progressing to full blown type 2 diabetes are equally effective for both sexes at preventing progression and reducing weight, according to a systematic review and meta-analysis. The research by Dr Anna Glechner, Danube University Krems, Austria, and Dr Jurgen Harreiter, Medical University of Vienna, Austria, and colleagues, was published in Diabetologia.

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