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breast cancer

Sustained weight loss associated with reduced breast cancer risk

A large study has found that women who lost weight after age 50 and kept it off had a lower risk of breast cancer than women whose weight remained stable, helping answer a vexing question in cancer prevention. The reduction in risk increased with the amount of weight lost and was specific to women not using postmenopausal hormones.

Weight loss lowers breast cancer risk for postmenopausal women

In a study of postmenopausal women, participants who lost weight had a lower risk of developing invasive breast cancer than those who maintained or gained weight, the findings suggest that weight loss may help lower postmenopausal women's breast cancer risk.

Bariatric surgery may counter genetic risk of breast cancer

Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop a malignancy than women with the same genetic risk who underwent bariatric surgery, according to a study presented by Cleveland Clinic Florida researchers at the 36th American Society for Metabolic and Bariatric Surgery (ASMBS) Annual Meeting at ObesityWeek 2019.

Researchers reveal how obesity promotes breast cancer

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells making them more aggressive as a result, according to research by scientists from Helmholtz Zentrum München, Technische Universität München (TUM) and Heidelberg University Hospital, Germany.

Breast cancer subtype influenced by type of obesity

Obese women with large bellies may be at risk of developing a different subtype of breast cancer than those with widespread fat accumulation, according to a study published in The Oncologist. The research suggests that the link between breast cancer and obesity may be more complex than previously thought.

Bariatric surgery beats diet at inhibiting breast cancer

Bariatric surgery was more effective than a low-fat diet at reversing the cancer-promoting effects of chronic obesity in mice, according to a study by UNC Lineberger Comprehensive Cancer Center researchers, who presented ‘Surgical weight loss via sleeve gastrectomy, but not a low-fat diet, reverses the pro-tumorigenic effects of obesity’, at the 2016 American Association of Cancer Research Annual Meeting in New Orleans.

Breast cancer survivors gain weight faster vs. cancer-free peers

Breast cancer survivors with a family history of the disease, including those who carry BRCA1 and BRCA2 gene mutations, gained more weight over the course of four years than cancer-free women especially if they were treated with chemotherapy, according to a prospective study by Johns Hopkins Kimmel Cancer Center researchers. Data from earlier studies suggest that breast cancer survivors who gain weight may have a higher risk of having their cancer return, the researchers note, adding that gains of 11lbs or more are also associated with a higher risk of developing cardiovascular disease.

Obesity increases breast cancer risk in postmenopausal women

An analysis of extended follow-up data from the Women's Health Initiative clinical trials suggests that postmenopausal women who were overweight and obese had an increased risk of invasive breast cancer compared to women of normal weight, according to an article, ‘Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk - A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trials’, published online by JAMA Oncology.

Obesity could affect breast cancer treatment

Obesity may affect a common drug that is used as part of the treatment to fight breast cancer in post-menopausal women, according to researchers from the University of Auckland, Australia.

Aromatase inhibitors stop the production of oestrogen in post-menopausal women by blocking the enzyme aromatase, which turns the hormone androgen into small amounts of oestrogen in the body. This means that less oestrogen is available to stimulate the growth of hormone-receptor-positive breast cancer cells.

Obesity and diabetes impact breast cancer outcomes

Obesity and diabetes have adverse effects on outcomes in breast cancer patients who receive chemotherapy as primary treatment before surgery (neoadjuvant chemotherapy), according to research presented at the 9th European Breast Cancer Conference (EBCC-9). Although a high BMI is known to have a negative impact on cancer development and prognosis, until now there has been uncertainty as to whether having a high BMI had an equal effect on patients with different types of breast tumours.

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