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Glucagon-like Peptide 1 (GLP-1)

Infusion of three hormones aids weight loss in patients with obesity

A small study examining the effects of subcutaneous infusion of three hormones - glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM) and peptide YY (PYY) collectively known as ‘GOP’ - on glycaemia and body weight has report that patients lost on average 4.4kg and the treatment led to substantial improvements to their blood glucose, with some patients' reducing to near-normal levels.

Faecal microbiota transplantation for obesity shows progress

Using capsules filled with faecal matter from a lean donor, researchers successfully changed some of the composition of the gut microbiota of patients with obesity, a possible step toward a new treatment for weight loss.

Bariatric surgery changes glucose management especially GLP-1

How bariatric surgery helps people with obesity and diabetes is related to changes in the way the gut senses food and nutrients after the operation, according to researchers from the Cambridge University Metabolic Research Laboratories at the Wellcome Trust - MRC Institute of Metabolic Science. They found that following surgery, altered patterns of digestion and absorption lower in the gut trigger production of higher levels of gut hormones, especially glucagon-like peptide 1 (GLP-1), which in turn causes higher insulin production.

Research on T2DM remission may lead to surgical alternatives

New findings on the reasons for T2DM remission after bariatric surgery may be the key to developing drug alternatives to surgery, according to researchers from the College of Veterinary Medicine. Type 2 diabetes develops due to two issues: islet dysfunction in the pancreas, and insulin resistance that's generally associated with obesity. Pancreatic islets produce important hormones for the body, including insulin. If they are not functioning correctly, insulin cannot move glucose out of the blood.

Sensory neurons show how surgery achieves weight loss

The vagus nerve has long been recognised as the internal sensory system, regulating breathing and heart rate among, as well as sensing and signalling that feeling of fullness to the brain. That same nerve also detects nutrients and controls digestion. Yet how it receives the information it uses to perform these tasks has been less well-known.

GLP-1 and EndoBarrier improves diabetes and obesity

Combining a temporary one-year intestinal bypass device with the drug liraglutide helps patients lose weight and improve their diabetes control better than using either the device or the drug alone, according to researchers from the United Kingdom. The one-year results of the two-year Randomisation to Endobarrier alone Versus with Incretin analogue in SustainEd Diabesity (REVISE-Diabesity) clinical trial and supported by the Association of British Clinical Diabetologists (ABCD), were presented at ENDO 2016, the annual meeting of the Endocrine Society in Boston.

GLP-1 reduction leads to over consumption of high fat foods

A study from Rutgers Robert Wood Johnson Medical School published in Cell Reports, has found that when the hormone glucagon like peptide-1 (GLP-1) was reduced in the central nervous system of laboratory mice, they overate and consumed more high fat food.

GLP-1 treatment prevents bone loss during weight loss

Using the intestinal hormone glucagon-like peptide 1 (GLP-1) in obesity treatment prevents the loss of bone mass otherwise frequently associated with major weight loss, according to a study from the University of Copenhagen, Hvidovre and Glostrup Hospital, Denmark. According to the researchers behind the study, the results may have a significant bearing on future obesity treatment.

Study links GLP-1 to increased risk of colon cancer

Previous studies have indicated that bariatric surgery could result in an increased risk of developing colon cancer and now researchers from Mount Sinai Hospital in Toronto, Canada, think they may know why. They believe that as much of the stomach and small intestine is bypassed, the food that is consumed is not completely broken down when it reaches the large intestine, or colon.

Hormone causes hypoglycaemia after bypass surgery

Blocking the action of one of the gut hormones can correct post-meal hypoglycaemia in gastric bypass patients, according to researchers at the University of Cincinnati (UC). The study, published the journal Gastroenterology, is part of an ongoing effort by UC researchers to better understand glucose metabolism after weight-loss surgery.

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