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Sigrid Therapeutics’ SiPore15 prevents weight gain in mice

Sigrid Therapeutics has announced the publication of a major study in mice demonstrating the enzyme-blocking effects of mesoporous silica particles (MSPs) introduced to the gut and the resulting effect on food efficiency and metabolic risk factors. Sigrid has previously performed clinical studies demonstrating that SiPore15 lowers blood sugar levels, measured as HbA1c.

Gastric banding more effective than metformin in treating T2DM

People with prediabetes or new-onset type 2 diabetes who had gastric banding had similar stabilisation of their disease to those who took metformin alone, according to a study supported by the National Institutes of Health.

Weight loss drug lorcaserin has positive effect on diabetes

Investigators from the Thrombolysis in Myocardial Infarction (TIMI) Study Group have reported that lorcaserin (Belviq), a weight loss drug manufactured by Eisai who is sponsoring the CAMELLIA-TIMI 61 clinical trial, demonstrated sustained weight loss without an increased risk of major cardiovascular events (MACE). The diabetes-related findings from CAMELLIA-TIMI 61, a clinical trial of overweight and obese patients designed to test lorcaserin, were presented at the 2018 Meeting of the European Association for the Study of Diabetes by researchers from the Brigham and Women's Hospital.

Lack of sleep associated with higher BMI in people with prediabetes

People with prediabetes who go to bed later, eat meals later and are more active and alert later in the day - those who have an ‘evening preference’ - have higher BMI compared with people with prediabetes who do things earlier in the day, or exhibit morning preference, according to a University of Illinois at Chicago-led study. That also reported that the higher BMI among people with evening preference is related to their lack of sufficient sleep.

Western diet linked to vascular damage and prediabetes

Short-term exposure to the average American diet increase the risk of developing diabetes and cardiovascular disease, according to a study funded by researchers from New York Institute of Technology College of Osteopathic Medicine (NYITCOM).  Research from NYITCOM has proven that the western diet can cause equally unsettling results among females, a population which possesses protective hormones aiding in the prevention of cardiovascular diseases. The study the was funded by the American Heart Association.

More than 100 million Americans have diabetes or prediabetes

More than 100 million US adults are now living with diabetes or prediabetes, according to a report by the Centers for Disease Control and Prevention (CDC). The report finds that as of 2015, 30.3 million Americans – 9.4 percent of the US population –have diabetes. Another 84.1 million have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years.

Liraglutide adds non-diabetic overweight and obese

For people with prediabetes who are overweight or obese, adding 3.0mg of liraglutide for three years to a diet and exercise plan may lead to major health improvements, according to outcomes from the SCALE (Satiety and Clinical Adiposity - Liraglutide Evidence) trial, in a presentation, ‘OR36-1 Liraglutide 3.0 Mg Reduces Body Weight and Improves Cardiometabolic Risk Factors in Adults with Obesity or Overweight and Prediabetes: The Scale Obesity and Prediabetes Randomized, Double-Blind, Placebo-Controlled 3-Year Trial’, presented at ENDO 2016, the annual meeting of the Endocrine Society, in B

Lifestyle interventions most cost-effective approach

Behavioural and drug interventions aiming to prevent people with prediabetes progressing to full blown type 2 diabetes are equally effective for both sexes at preventing progression and reducing weight, according to a systematic review and meta-analysis. The research by Dr Anna Glechner, Danube University Krems, Austria, and Dr Jurgen Harreiter, Medical University of Vienna, Austria, and colleagues, was published in Diabetologia.

Prediabetes increases the risk of cancer by 15 percent

A meta-analysis comprising 16 studies and 891,426 participants from various regions of the world shows that prediabetes increases the risk of cancer by 15%, with differing risks depending on the type of cancer. The study authors lead by Professor Yuli Huang, The First People's Hospital of Shunde, Daliang Town, Shunde District, China, and colleagues performed meta-analysis to evaluate the risk of cancer in association with the impaired fasting glucose and impaired glucose tolerance population.

England: One in three adults has prediabetes

One in three adults in England has prediabetes according to a paper published in the British Medical Journal. The number of adults with prediabetes has increased from 11.6% in 2003 to 35.3% in 2011.

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