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News about clinical research: trials, studies, case reports, etc.

Gut microbiota imbalance promotes the onset of colorectal cancer

The gastroenterology team at Henri-Mondor AP-HP Hospital and University Paris-Est Créteil, led by Professor Iradj Sobhani, together with teams from Inserm and the Institut Pasteur Molecular Microbial Pathogenesis Unit (U1202), led by Professor Philippe Sansonetti (holder of the Microbiology and Infectious Diseases Chair at the Collège de France) have demonstrated that an imbalance in the gut microbiota, also known as ‘dysbiosis’, promotes the onset of colorectal cancer.

Obesity-related cancers are increasing in young Canadians

The overall rate of new cancer cases is decreasing in men but increasing in women younger than 80 years, and obesity-related cancers are increasing in young people, according to a study on cancer trends in Canada from 1971 to 2015.

Bariatric surgery may prevent strokes and extend life expectancy

Patients with obesity who undergo bariatric surgery live longer and are less likely to experience a clot-caused stroke than those who do not, according to preliminary research to be presented at the American Heart Association's Scientific Sessions 2019, in Philadelphia.

Surgery activates vagal stretch sensors reducing appetite

Researchers from UC San Francisco have suspected for some time that one reason bariatric surgery is so surprisingly effective at blocking hunger is that it causes food to pass very rapidly from the stomach into the intestine, but the mechanism has been unknown. New findings suggest an answer: that rapidly incoming food stretches the intestine, thereby activating the vagal stretch sensors and powerfully blocking feeding.

Majority of diet trials amend their outcome measures

The vast majority of clinical trials involving diet amended their desired study outcomes along the way raising the possibility of bias, according to researchers from Boston Children's Hospital, and Pennington Biomedical Research Center (Baton Rouge, LA).

Studies demonstrate the effectiveness of post-op liraglutide

Liraglutide can be considered as a safe and effective adjunctive treatment to prevent weight regain after bariatric surgery, according to two studies presented at the UK’s Society for Endocrinology annual conference.

In the first study, ‘Efficacy of liraglutide in weight management post bariatric surgery patients: data from an Emirati cohort’, researchers from Imperial College London Diabetes Centre, Abu Dhabi, UAE, assessed the use of Liraglutide for relapse after bariatric surgery in an Emirati population.

Post-op kidney disease outcomes differ between teens and adults

Adolescents with T2DM experienced more hyperfiltration and earlier attenuation of their elevated urine albumin-to-creatinine ratio (UACR) after gastric bypass surgery compared with adults, according to the abstract, ‘Five-year kidney outcomes of bariatric surgery in adolescents compared with adults’, presented during the American Society of Nephrology's Kidney Week 2019.

Risk of long-term nutritional deficiencies for post-op teens

Adolescents who have bariatric surgery may develop nutritional deficiencies years after treatment that can result in health risks if not properly managed, according to researchers at the Cincinnati Children's Hospital Medical Center. In addition, they report gastric bypass appears to cause more nutritional disruption than vertical sleeve gastrectomy.

Age not a barrier to the benefits of bariatric surgery

A study has revealed that bariatric surgery can lead to successful weight loss and better diabetes control in older adults (above the age of 65). The study, presented at the Society for Endocrinology annual conference in Brighton, UK, indicates that elderly patients treated with either gastric bypass or gastric sleeve can recover well and have a reduced risk of obesity-related complications, including heart disease and diabetes.

Vitamin D supplements do not reduce risk of inflammation

Vitamin D and marine omega-3 fatty acids are purported to have many health benefits, including reducing systemic inflammation. Signals of systemic inflammation are tied to diseases of aging and obesity, including cardiovascular disease, heart failure, osteoporosis, diabetes and some cancers, and neurodegenerative diseases such as Alzheimer's disease.

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