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News about clinical research: trials, studies, case reports, etc.

SAGES and EAES recommendations for surgical response to COVID-19

The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) and the European Association for Endoscopic Surgery (EAES) has released recommendations based on best available evidence and expert opinion from the global surgical community that will help to protect patients, their surgeons and staff from COVID-19.

The joint statement states that the virus has demonstrated a propensity to spread at an exponential rate in several countries, significantly impacting many lives and affecting our practice as healthcare professionals. The statement recommends that:

Large variation in the causes of childhood obesity worldwide

The factors causing childhood obesity are different for wealthier and poorer countries, and the management of the disease is complex, according to a report by Yale scientists. According to one study cited in the report, BMI data from 200 countries showed paediatric obesity has risen from 4% in 1975 to 18% in 2016 or from 5 million to 50 million girls and 6 million to 74 million boys.

Childhood overweight and obesity rates increase for disadvantaged families

Although the overall prevalence of overweight and obesity in children and adolescents has fallen slightly over the past decade, the rates of both conditions have increased in the most disadvantaged neighbourhoods, according to a study that included more than one million children in Catalonia, Spain, which was carried out by the Barcelona Institute for Global Health (ISGlobal) - a centre supported by ‘la Caix’ - and the IDIAPJGol Institute.

World Obesity issues COVID-19 statement

World Obesity has issues a statement concerning obesity and of COVID-19 stating that obesity-related conditions seem to worsen the effect of COVID-19 indeed, the Centers for Disease Control and Prevention (CDC) reported that people with heart disease and diabetes are at higher risk of COVID-19 complications.

COVID-19: Analysis on numbers in intensive care from Italy

A new report on COVID-19 data to March 18 from Italy, prepared by an Italian expert for the European Society of Anaesthesiology (ESA), states that the rate of increase in the number of patients in intensive care units (ICU) with COVID-19 in Italy may have peaked in Lombardy, and may still be peaking in Italy as a whole. The report is by Davide Manca, Professor of Process Systems Engineering at Politecnico di Milano, Milan, Italy.

Misfolded proinsulin is early sign of type 2 diabetes

According to a study by scientists at Sanford Burnham Prebys and the University of Michigan Medical School, misfolded proinsulin - a protein the body normally processes into insulin - is an early sign of type 2 diabetes. The discovery could lead to tests or treatments that help prevent people from developing type 2 diabetes.

Significantly fewer heart attacks and strokes for bariatric patients

Bariatric surgery resulted in 60% fewer fatal and non-fatal heart attacks and strokes among 3,701 men and women who had surgery, compared to the same number of patients who did not, during an average of 11 years following the surgery. In addition, patients who had bariatric surgery lost significantly more weight (an average of over 10 kg more) and type 2 diabetes was more likely to improve to the point where the patients no longer required medication to maintain normal blood sugar levels.

Bypass patients maintain 20% weight loss vs 5% non-surgical

People with severe obesity who underwent bariatric surgery maintained significantly more weight loss at five years than those who did not have surgery, according to a Kaiser Permanente study. Although some weight regain was common after surgery, regain to within 5% of baseline was rare, especially in patients who had gastric bypass instead of sleeve gastrectomy.

Manipulating microbes could be an alternative to bariatric surgery

Researchers generally agree that genetic and gut microbiome composition and activity are important factors in determining who has and who does not have obesity. As interest and understanding of the human microbiome increases, researchers are increasingly looking to the gut for answers that can lead to new, more effective diagnostics and therapies.

Bariatric surgery reduces CRC risk in patients with obesity

Bariatric surgery significantly reduces colorectal cancer (CRC) risk in patients with obesity to the extent that they share the same risk of colorectal cancer as the general population, according to researchers from Université Côte d’Azur, Nice, France. However, for patients with obesity who do not undergo bariatric surgery, the risk is 34% above that of the general population.

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