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Surgery activates vagal stretch sensors reducing appetite

Researchers from UC San Francisco have suspected for some time that one reason bariatric surgery is so surprisingly effective at blocking hunger is that it causes food to pass very rapidly from the stomach into the intestine, but the mechanism has been unknown. New findings suggest an answer: that rapidly incoming food stretches the intestine, thereby activating the vagal stretch sensors and powerfully blocking feeding.

New mutation in leptin gene may explain excess of body fat

Researchers at Texas Biomedical Research Institute, San Antonio, TX, have discovered a new mutation in the gene that regulates the key hormone suppressing hunger called leptin. This new mutation could help researchers understand why people develop excess of body fat. The research is aimed at helping tackle metabolic disorders like cardiovascular disease and diabetes which are fuelled by obesity and impact millions of people around the world.

Plasma leptin concentrations are not limited to the brain

Yale researchers have offered insight into leptin - a hormone that plays a key role in appetite, overeating and obesity - heir findings advance knowledge about leptin and weight gain, and also suggest a potential strategy for developing future weight-loss treatments, they said.

How the brain influences our eating habits and weight gain

Two separate teams of researchers have identified how genes involved in neural development can affect body weight and how brain cells involved in memory play an important role after a meal in reducing future eating behaviour. The first team – led by investigators at the University of Cambridge and Children's Hospital Los Angeles (CHLA) have pinpointed a set of molecules that wire the body weight centre of the brain.

3D imaging technique tracks satiety hormone Leptin

Many overweight people lack the feeling of being full and it was believed that this was due to the disrupted transport of the satiety hormone leptin to the brain. However, a group of scientists from Helmholtz Zentrum München, Germany, have now shown with a new 3D imaging technique – which allows tracking the path of the hormone in the brain – that this is not the case.

Researchers characterise keyhole hunger receptor

An international team has uncovered the potential to beat obesity at the cellular level, characterising for the first time a complex, little-understood receptor type that, when activated, shuts off hunger.  The team led by Professor Jens Meiler, professor of chemistry and pharmacology at Vanderbilt University, said pharmaceutical companies long have attempted to develop a small-molecule drug that could do just that.

Hunger and satiety hormones both rise after weight loss

The levels of hormones that control hunger and satiety both rise after weight loss, but individuals may only experience an increase in hunger, according to researcher from the Norwegian University of Sciences and Technology, Trondheim, Norway and the University of Copenhagen, Denmark.

Insulin in the brain suppresses hunger feeling

Insulin in the brain may help regulate the hunger sensation and improve functional connectivity in the default-mode network (DMN), as well as in the hippocampus and hypothalamus, according to the findings of a study by researchers at the German Center for Diabetes Research (DZD) in Tübingen, Germany.

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