Most recent update: Thursday, November 21, 2019 - 11:01

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gene expression

Insulin receptor and gene expression leads to new research

Researchers from Harvard Medical School have made key new insights into the molecular behaviour of insulin via an unexpected mechanism by which insulin triggers changes to the expression of thousands of genes throughout the genome. Their analyses show that the insulin receptor - a protein complex at the cell surface - physically transports to the cell nucleus after it detects and binds insulin. Once there, it helps initiate the expression of genes involved in insulin-related functions and diseases. This process was impaired in mice with insulin resistance.

Weight changes alters molecular microbiome and gene expression

The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine. They found that as people gain or lose excess weight they exhibit notable changes in their microbiome, cardiovascular system, immune system and levels of gene expression.

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