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BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

Transoral outlet reduction (TORe) and anastomotic reduction techniques are gaining momentum as minimally invasive alternatives to surgical revision for managing post-surgical complications such as weight regain and dumping syndrome.(1) BARS® — a novel endoscopic platform developed by Ovesco Endoscopy AG — is among the emerging technologies in this field. As clinical experience with BARS® grows, early data on weight regain management and targeted treatment approaches for enlar

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

BariClip delivers significant reductions in BMI, %TWL and %EWL at six months

Loose fundoplication utilising the excluded stomach into OAGB improves HRQoL vs OAGB alone

Research

First patient treated in EASE clinical trial evaluating the EndoZip Automated Suturing System for ESG

The first patient has been treated in Nitinotes’ US Investigational Device Exemption (IDE) EASE Clinical Trial evaluating the EndoZip Automated Suturing System for endoscopic sleeve gastroplasty (ESG). The procedure was performed at Lenox Hill Hospital | Northwell Health in New York, NY, the trial's first activated US site. The EASE Clinical Trial is a prospective, multi-centre, randomised, two-arm, blinded pivotal study designed to evaluate the safety and effectiveness of th

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

GLP-1 receptor agonists likely have little or no effect on obesity-related cancer risk

A systematic review and meta-analysis that evaluated the risk for obesity-related cancer associated with glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes (T2D) or overweight or obesity, has found that the drugs probably have little or no effect on risk for thyroid, pancreatic, breast, or kidney cancer and may have little or no effect on other obesity-related cancers. However, the researchers from Harvard Medical School stated the certainty

PFAS exposure may limit improvements in blood sugar after MBS

Researchers from the Keck School of Medicine (University of Southern California) have found that teenagers with higher blood levels of per- and polyfluoroalkyl substances (PFAS) measured before metabolic bariatric surgery (MBS) had smaller improvements in blood sugar over five years, including fasting glucose and haemoglobin A1c (HbA1c), which measures average blood sugar levels over the past 60–90 days. The results, suggest that PFAS exposure may help explain why metabolic o

BariClip delivers significant reductions in BMI, %TWL and %EWL at six months

Laparoscopic vertical clip gastroplasty (LBCG) using the nonadjustable BariClip is a safe and effective bariatric procedure in the short term, with significant reductions in BMI, %TWL and %EWL observed over a six-month period, according to a retrospective observational study by researchers from Jordan. Figure 1: Schematic illustration of laparoscopic vertical clip gastroplasty using the nonadjustable BariClip system, showing the placement of the clip along the stomach to cre

Journal watch 3/12/2025

Welcome to our regular round-up of the latest bariatric and obesity-related papers published in the medical literature. As ever, we have looked far and wide to give you an overview of papers including FundoRing-OAGB modification, magnet-assisted bariatric surgery, Bariclip, ring-augmented sleeve gastrectomy and the SURMOUNT-4 Trial, and more (please note, log-in maybe required to access the full paper). Comparative endoscopic ultrasound assessment of the gastric pouch after F

Gastric mucosal ablation with MOVIVA: Setting new standards in endoscopic bariatric treatment

Just a few months after the world’s first gastric mucosal ablation (GMA) case using MOVIVA (Erbe Elektromedizin) at the Policlinico Universitario Agostino Gemelli in Rome, clinical experience is rapidly expanding across Europe. With around 80 procedures performed within a short timeframe in eight countries, MOVIVA is helping to establish a new era of endoscopic bariatric treatment – offering a less invasive option as obesity rates continue to rise worldwide. Gastric mucosal a

WHO issues global guideline on the use of GLP-1 medicines

The World Health Organization (WHO) has released its first guideline on the use of Glucagon-Like Peptide-1 (GLP-1) therapies for treating obesity as a chronic, relapsing disease, to address the growing global health challenge of obesity that affects more than one billion people. In 2024, obesity was associated with 3.7 million deaths worldwide and without decisive action, the number of people with obesity is projected to double by 2030. In September 2025, WHO added GLP-1 ther

REVEAL-1: Sustained post-GLP-1 weight maintenance after a single Revita procedure

Fractyl Health has announced positive 6-month results from its open-label REVEAL-1 Cohort. The REVEAL-1 Cohort is an open-label study in individuals with obesity who have lost at least 15% of their total body weight on a GLP-1 medication and who either need or choose to discontinue GLP-1 therapy. The REVEAL-1 data show that patients who underwent a single Revita procedure after discontinuing GLP-1 therapy maintained both stable body weight and glycaemic control through 6 mont

Ascletis selects ASC37, first oral GLP-1R/GIPR/GCGR triple peptide agonist for clinical development

Ascletis has selected ASC37 oral tablets, its first oral GLP-1R/GIPR/GCGR[1] triple peptide agonist, as a clinical development candidate. Ascletis expects to submit an Investigational New Drug Application (IND) to the FDA for ASC37 oral tablets for the treatment of obesity in the second quarter of 2026. ASC37 oral tablets is the company's first incretin drug candidate developed with its proprietary Peptide Oral Transport ENhancement Technology (POTENT). ASC37, a GLP-1R, GIPR,

UT Health San Antonio leads study on glucagon hormone’s role in human metabolism

A clinical research team at UT Health San Antonio, the academic health centre of The University of Texas at San Antonio, has been awarded a five-year, nearly $4 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases for a first-of-its-kind study to explore the many roles glucagon plays in human metabolism. Glucagon historically was seen only as insulin’s counterbalance, raising blood sugar during periods when i

Early obesity and low choline levels linked to brain inflammation risk that can speed up cognitive decline and increase the risk of Alzheimer's disease

For decades, scientists have known that what harms the body often harms the brain. Conditions such as obesity, high blood pressure and insulin resistance strain the body's vascular and metabolic systems. Over time, that stress can speed up cognitive decline and increase the risk of Alzheimer's disease. Now, researchers at Arizona State University and their collaborators report that these effects may begin far earlier than expected. This graphic shows how obesity in young adul

Industry

First patient treated in EASE clinical trial evaluating the EndoZip Automated Suturing System for ESG

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

Gastric mucosal ablation with MOVIVA: Setting new standards in endoscopic bariatric treatment

Novo Nordisk files for FDA approval of a higher dose of Wegovy injection 7.2 mg

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New: Directory

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Events

14th Congress of the European Chapter of the International Federation for the Surgery and Other Therapies For Obesity

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1 September 2026

XXIX IFSO World Congress

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3 December 2025

8TH Gulf Obesity Surgery Society International Conference

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Headlines

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

BariClip delivers significant reductions in BMI, %TWL and %EWL at six months

Loose fundoplication utilising the excluded stomach into OAGB improves HRQoL vs OAGB alone

Research

First patient treated in EASE clinical trial evaluating the EndoZip Automated Suturing System for ESG

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

GLP-1 receptor agonists likely have little or no effect on obesity-related cancer risk

PFAS exposure may limit improvements in blood sugar after MBS

BariClip delivers significant reductions in BMI, %TWL and %EWL at six months

Journal watch 3/12/2025

Gastric mucosal ablation with MOVIVA: Setting new standards in endoscopic bariatric treatment

WHO issues global guideline on the use of GLP-1 medicines

REVEAL-1: Sustained post-GLP-1 weight maintenance after a single Revita procedure

Ascletis selects ASC37, first oral GLP-1R/GIPR/GCGR triple peptide agonist for clinical development

UT Health San Antonio leads study on glucagon hormone’s role in human metabolism

Early obesity and low choline levels linked to brain inflammation risk that can speed up cognitive decline and increase the risk of Alzheimer's disease

Industry

First patient treated in EASE clinical trial evaluating the EndoZip Automated Suturing System for ESG

BARS® for anastomotic reduction – Clinical insights on associated weight regain and dumping syndrome

Gastric mucosal ablation with MOVIVA: Setting new standards in endoscopic bariatric treatment

Novo Nordisk files for FDA approval of a higher dose of Wegovy injection 7.2 mg

All caught up?

New: Directory

Discover global suppliers of specialist bariatric services, treatments, products, and medical equipment.

Events

(See all)

4th IFSO MENAC Meeting

BOMSS ASM 2026

6th London International Bariatric Surgery Symposium (LIBSS)

2026 IBC University of Oxford World Congress

14th Congress of the European Chapter of the International Federation for the Surgery and Other Therapies For Obesity

XXIX IFSO World Congress

8TH Gulf Obesity Surgery Society International Conference

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