Time to read
3 minutes
Read so far

Weight loss before knee surgery may not be beneficial for people with OA

Tue, 02/02/2021 - 14:07
Posted in:

Researchers from the University of Alberta have reported that losing weight before knee replacement surgery does not lead to better outcomes for patients. In a systematic review, researchers in the Faculty of Rehabilitation Medicine found that weight loss before surgery may not be beneficial for people with advanced knee osteoarthritis. Their findings, ‘A critical review of weight loss recommendations before total knee arthroplasty’, were published in Joint Bone Spine journal.

Osteoarthritis affects more than 300 million people worldwide, with the knee being the most common joint affected. Factors like aging and obesity have increased the number of Canadians having knee replacements by more than 22 per cent in the past five years, with more than 75,000 surgeries now performed each year.

Medical practitioners have long advised patients to lose weight before knee surgery. Patients living with obesity are especially warned of surgical complications, risk of infection and poor outcomes due to their high BMI.

"While there's evidence that a higher BMI equals a potentially higher surgical risk, that doesn't mean that if a patient reduces their BMI, even a point or two, that it would be good for them," said lead author, Dr Kristine Godziuk, a postdoctoral fellow in the Department of Occupational Therapy.

The research team reviewed clinical practice guidelines and other clinically influential literature from the past ten years for evidence that weight loss is helpful for patients.

The study calls into question the use of BMI as a determinant of patient outcomes for orthopaedic surgery. For example, patients with higher BMIs are not eligible for knee replacement until they lower their BMI or lose weight. As a result, those patients spend more time on the waiting list, Godziuk said. Before the COVID-19 pandemic, wait times for knee surgery in Alberta averaged between 14 months and two years.

For the study, the team examined the current evidence supporting weight loss in adults with obesity and advanced knee osteoarthritis and focused on three key areas: 1) knee replacement surgery complication risk with severe obesity compared to obesity (BMI ≥40 kg/m2 versus 30.0-39.9 kg/m2); 2) weight loss recommendations for individuals with advanced knee osteoarthritis; and 3) knee replacement surgery outcomes after pre-surgical weight loss.

They reported that the current literature does not show a clear relationship between weight loss and reduction in TKA complications, and no indication that a patients’ individual risk is lowered by reducing their BMI from a threshold of ≥40 kg/m2 to ≤39.9 kg/m2. Studies that have found a benefit of weight loss for knee osteoarthritis have not included patients with higher BMIs (≥40 kg/m2) or more advanced knee osteoarthritis.  In addition, there report there is ‘unclear evidence’ of a benefit of pre-surgical weight loss on knee replacement surgery outcomes. These are important evidence gaps, suggesting that recommendations for BMI reduction prior to knee replacement surgery should be tempered by the current uncertainty in the literature.

"Patients with a higher BMI wait even longer because they're told to go try to lose weight first, so by the time they go to get surgery they're maybe in worse condition than if they hadn't tried that first. It's very challenging to lose weight and keep it off," said Godziuk. "We know that age is associated with increased surgical risk with knee replacement surgery, but we don't tell people, 'Well, you have to be younger than 70.' We don't do those cut-offs for age, but we do them for BMI, which ends up creating this bias in access to care."

Not only does using BMI as a determinant limit surgical access, Godziuk said, but it can risk patients' health, since short-term weight loss that cannot be maintained has few benefits, and could potentially be harmful.

"We tell patients to go lose weight, to lower their BMI, but it can be harmful to have that blanket recommendation. What we're suggesting is that maybe we don't tell them to lose weight, but help them to prevent weight gain. Maybe that's a better message to send to patients, and through that we can also support them to improve their body composition and overall health."

Godziuk said working in paediatric obesity helped her understand the need for more research in this area.

"I could see clinically, when I worked with adolescents, that BMI was a poor measure for them, and I know it's a poor measure in adults. When we just rely on these simple metrics, I could see that there was this gap. And it's so important from a rehabilitation perspective—to help patients live with osteoarthritis and manage it, including if they have obesity as well."

Practitioners should be aware of the lack of evidence for weight loss before surgery and reconsider recommendations about BMI, Godziuk said.

"We do such a good job of looking more in depth into all other areas of a person's health, but to distill obesity down to BMI, we're missing some information. We're not saying that everyone with a high BMI should have knee surgery, but we're calling into question the way it's being assessed, that BMI alone is missing some things."