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Major weight loss driver of post-surgical metabolic benefits

Thu, 08/20/2020 - 14:12
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Researchers from Washington University School of Medicine in St Louis have suggested that weight loss after bariatric surgery, rather than the surgery itself, drives metabolic improvements such as the remission of diabetes. Their findings were published in the paper, ‘Effect of diet versus gastric bypass on metabolic function in diabetes’, in The New England Journal of Medicine.

The researchers studied 11 patients with severe obesity with diabetes who had gastric bypass surgery and then lost 18% of their body weight. The investigators then compared those patients with 11 patients with severe obesity with diabetes but had lost the same percentage of body weight through diet alone.

After reaching their weight-loss goals, members of both groups experienced similar improvements in metabolism such as lower blood sugar levels throughout the day, better insulin action in the liver, muscle and fat tissue, and reductions in the need for insulin and other diabetes medications. Since the group that lost weight through diet alone did just as well as the surgery group, the researchers concluded the improvements were due to weight loss alone, rather than to any physiological changes that resulted from the surgery itself.

"It has been presumed that gastric bypass surgery has therapeutic, metabolic effects that result in better glucose control and even remission of diabetes beyond the effects expected from weight loss alone," said principal investigator, Dr Samuel Klein, director of Washington University's Center for Human Nutrition. "But we found gastric bypass surgery improves metabolic function by causing weight loss. There were no differences in the reduction of diabetes medications or in the rate of diabetes remission between surgery patients and those who lost equivalent amounts of weight through diet alone."

Samuel Klein
Samuel Klein

The average age of patients in the diet group was about 55, while the average in the surgery group was 49. Those in the surgery group lost an average of 51 pounds, while those in the diet group lost an average of 48 pounds. All study patients maintained that weight loss for several weeks before follow-up studies were performed.

Over a 24-hour period, the researchers measures study subjects' metabolic responses to meals. They measured insulin sensitivity in the liver, in fat tissue and in muscle tissue, as well as analysing the response of insulin-secreting beta cells in the pancreas and blood fatty acid concentrations, all of which contribute to the development of type 2 diabetes.

"It has been suggested that weight loss induced by gastric bypass surgery is different from weight loss induced by a low-calorie diet, based on the fact that certain factors - such as increased bile acid concentrations, decreased branched-chain amino acid concentrations and alterations in the gut microbiome - are different in surgery patients and may be responsible for the unique therapeutic effects of gastric bypass surgery," Klein said. "We found all of those factors were, in fact, different after weight loss in surgery patients than in patients who lost weight through diet alone. Yet those changes were not associated with any physiologically or clinically important metabolic benefits."

According to Klein, also the William H Danforth Professor of Medicine and Nutritional Science and chief of the Division of Geriatrics and Nutritional Science, the loss of weight is the reason for improvements in metabolic function and reversal of diabetes. Weight loss through dieting produces the same beneficial metabolic effects as weight loss following surgery.

In an accompanying editorial, ‘Bariatric Surgery and Restoration of Insulin Sensitivity - It’s Weight Loss’, in the journal about the paper, researchers from Tufts University, Harvard University, Massachusetts General Hospital and the University of Maine write that the study "delivers a straightforward and important message for both clinicians and patients - reducing adipose tissue volume, by whatever means, will improve blood glucose control in persons with type 2 diabetes."

"However, losing 18% of body weight with diet therapy alone is extraordinarily difficult and unrealistic for most people with obesity," explained Klein. "In contrast, gastric bypass surgery leads to marked and sustained long-term weight loss, which makes it a potent therapy for people with diabetes."

Klein's study was focused on the effects of gastric bypass surgery on metabolic function and did not look at other medical complications associated with obesity.

"Our study does not exclude the possibility that gastric bypass surgery has unique weight loss-independent effects on important clinical outcomes such as arthritis, lung function or cancer risk, which were not assessed. But when it comes to metabolic health, gastric bypass surgery is effective because it causes weight loss," he concluded.

This study was partly funded by the National Institutes of Health.