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Device provides the feeling of fullness by stimulating the endings of the vagus nerve with light

Mon, 01/11/2021 - 09:34
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Researchers at Texas A&M have designed a device that stimulates the endings of the vagus nerve, which is responsible for the regulation of food intake and might help with weight loss via a simple operative procedure for implantation. Researchers said their centimeter-sized device provides the feeling of fullness by stimulating the endings of the vagus nerve with light. Unlike other devices that require a power cord, their device is wireless and can be controlled externally from a remote radio frequency source.

“We wanted to create a device that not only requires minimal surgery for implantation but also allows us to stimulate specific nerve endings in the stomach,” said Sung II Park, assistant professor in the Department of Electrical and Computer Engineering. “Our device has the potential to do both of these things in the harsh gastric conditions, which, in the future, can be hugely beneficial to people needing dramatic weight-loss surgeries.”

Their findings, ‘Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways’, were published in Nature Communications.

In recent years, the vagus nerve has received attention as a target for treating obesity since it provides sensory information about fullness from the stomach lining to the brain. Although there are medical devices that can stimulate the vagus nerve endings and consequently help in curbing hunger, these devices are similar in design to a pacemaker, with wires connected to a current source providing electrical jolts to activate the tips of the nerve.

Park said wireless technology, as well as the application of advanced genetic and optical tools, have the potential to make nerve stimulation devices less cumbersome and more comfortable for the patient.

“Despite the clinical benefit of having a wireless system, no device, as of yet, has the capability to do chronic and durable cell-type specific manipulation of neuron activity inside of any other organ other than the brain,” he said.

 

To fill this gap, Park and his team first used genetic tools to express genes that respond to light into specific vagus nerve endings in vivo. Then, they designed a tiny, paddle-shaped device and inserted micro LEDs near the tip of its flexible shaft, which was fastened to the stomach. In the head of the device, called the harvester, they housed microchips needed for the device to wirelessly communicate with an external radio frequency source. The harvester was also equipped to produce tiny currents to power the LEDs. When the radio frequency source was switched on, the researchers showed that the light from the LEDs was effective at suppressing hunger.

The researchers said they were surprised to uncover that the biological machinery coordinating hunger suppression in their experiments was different from conventional wisdom. It is widely accepted that when the stomach is full, it expands and the information about stretch is conveyed to the brain by mechanoreceptors on the vagus nerve.

“Our findings suggest that stimulating the non-stretch receptors, the ones that respond to chemicals in the food, could also give the feeling of satiety even when the stomach was not distended,” he said.

Looking ahead, he said the current device could also be used to manipulate nerve endings throughout the gastrointestinal tract and other organs, like the intestine, with little or no modifications.

“Wireless optogenetics and identifying peripheral neural pathways that control appetite and other behaviors are all of great interest to researchers in both the applied and basic fields of study in electronics, material science and neuroscience,” Park said. “Our novel tool now enables interrogation of neuronal function in the peripheral nervous systems in a way that was impossible with existing approaches.”

Other contributors to the research include Woo Seok Kim, Sungcheol Hong and Milenka K Gamero from the electrical and computer engineering department; Vivekanand Jeevakumar, Clay M Smithhart and Theodore J Price from The University of Texas at Dallas; and Richard D Palmiter and Carlos Campos from the University of Washington.

This work has been supported by grants from the interdisciplinary X-Grants Program, a NARSARD Young Investigator Award from the Brain and Behavior Research Foundation, the National Science Foundation’s Engineering Research Center for Precise Advanced Technologies and Health Systems (PATHS-UP) and the University of Washington Diabetes Research Center and the National Institutes of Health.

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