Gut hormones' regulation of fat production abnormal in obesity

The gut hormone FGF19, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign report. The study, ‘Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A’, published in Nature Communications, was led by molecular and integrative physiology professor Jongsook Kim Kemper and research scientist Young-Chae Kim.