Why losing weight is a battle with biology and your environment

Weight loss should not be the primary motivation behind healthy lifestyle changes, according to researchers from the University of Alberta, Canada, who claim that there is a growing body of research showing that upwards of 95 percent of those who achieve any sort of meaningful weight loss will pack it back on, and then some, within a couple of years.

Blood test can highlight risk of weight gain and diabetes

Researchers at the University of Campinas (UNICAMP) in São Paulo State, Brazil, have developed a computer program that analyses molecules in blood plasma to search for biomarkers that identify individuals who are at risk of becoming overweight and developing obesity-related diseases. The project was conducted in Brazil with funding from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) .

Gut bacteria involved in the development of type 2 diabetes

Bacteria may be involved in the development of type 2 diabetes, according to a study by researchers from Université Laval, the Québec Heart and Lung Institute (IUCPQ) and McMaster University. The authors found that the blood, liver and certain abdominal fat deposits in diabetics have a different bacterial signature than in non-diabetics.

How obesity causes hypertension and potential treatments

Researchers at the University of Virginia School of Medicine have discovered why obesity causes high blood pressure and identified potential ways of treating that form of high blood pressure. Small arteries in our body control blood pressure. Scientists have suspected that hypertension in obesity is related to problems in endothelial cells that line these small arteries. The reasons for this, however, have been unclear, until now. The researchers have already confirmed their discovery in human tissue samples and used it to reverse high blood pressure in lab mice.

Engineers to develop Virtual Bariatric Endoscopic Training Tool

A team of engineers from Rensselaer Polytechnic Institute is developing a virtual reality-based training device that can help train medical professionals to perform endoscopic sleeve gastroplasty (ESG). The device, known as a ViBE (Virtual Bariatric Endoscopic) simulator is being supported by a grant from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH).

More persistent improvements in glycaemic control for RYGB vs LSG

Roux-en-Y gastric bypass (RYGB) was associated with larger and more persistent improvements in glycaemic control and 25% lower rates of T2DM relapse compared with sleeve gastrectomy (SG) patients, according to the latest analyses from the National Patient-Centered Clinical Research Network (PCORNet) Bariatric Study.

Mice brain cells change shape after a meal impacting satiety

Researchers from the CNRS, Inrae, University of Burgundy, Université de Paris, Inserm and University of Luxembourg have just revealed the mechanisms in the brain that lead to feelings of satiety after eating – and involve a series of reactions triggered by a rise in blood glucose levels.  The study, ‘Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal’,  which was conducted on mice, was published in Cell Reports.

Gastric bypass surgery patients may face increased fracture risk

Patients who have bariatric surgery may face an elevated risk of bone fractures, according to a Swedish study investigating the association between different bariatric surgery procedures and fracture risk. The paper, ‘Fracture risk after three bariatric surgery procedures in Swedish obese subjects: up to 26 years follow‐up of a controlled intervention study’, published in the Journal of Internal Medicine

Obesity affects the ability to work especially in women over 50

Older workers with obesity are at a higher risk of prolonged sickness absence or losing their jobs for health reasons than those of normal weight, with women affected significantly more than men, according to researchers from the University of Southampton. The study studied investigated the association between BMI and prolonged sickness absence, cutting down at work and health-related job loss among 2,299 men and 2,425 women aged between 50 and 64 years.

Brain response to liraglutide may inform future treatments

A preclinical study from the Perelman School of Medicine at the University of Pennsylvania, has shown how the weight loss drug, liraglutide, crosses the brain's blood barrier to engage with a region of the brainstem known as the nucleus tractus solitarius (NTS), which is responsible for balancing food intake and energy expenditure. Filling this gap meets a need that has become a priority for researchers looking for new treatments to help fight the increasing rates of obesity.