Fat burning molecule that has implications for treatment of obesity

Researchers have identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.

Adipocytes cell's immune response makes obesity worse

Scientists at Cincinnati Children's and the University of Cincinnati College of Medicine have outlined the details of new cellular process that shows how adipocytes’ (fat calls) immune response worsens obesity. The team reports that type I interferons, a class of substances produced by immune cells also are produced by fat cells called adipocytes. These interferons drive a constant low-level, chronic immune response that amplifies "vigour” to a cycle of inflammation within white adipose tissue (WAT).

FDA approves United Imaging’ uMR OMEGA MRI for bariatric patients

United Imaging has received FDA clearance of the uMR OMEGA magnetic resonance imaging (MRI) scanner, the world’s first ultra-wide 75-cm bore. With the widest bore in the market at any field strength, uMR OMEGA provides a unique, patient-centric experience designed to accommodate a wide range of patients. With a 75-cm bore and 680lbs table capacity, uMR OMEGA addresses evolving demographics in the US community, not only improving patient comfort for all but creating, for the first time, an MRI for bariatric patients.

Nutrient sensing capacity of Enterochromaffin cells change after high-fat diet-induced obesity and metabolic disease

Investigators at Flinders University  have found that the nutrient sensing capacity of Enterochromaffin (EC) cells, which line the gastrointestinal tract and are the source of almost all serotonin in the body, change in mice under the influence of high-fat diet-induced obesity and metabolic disease.

Pseudogynecomastia: Flap technique retains nipple colour in men after significant weight loss

Surgeons at UT Southwestern Medical Center have pioneered a new technique that prevents nipple discoloration and preserves shape in men who undergo breast reduction surgery following significant weight loss. The procedure, described in the paper, ‘An Alternative Treatment of Pseudogynecomastia in Male Patients After Massive Weight Loss’, was published in the Aesthetic Surgery Journal Open Forum.

Families with better communication improve their eating habits

Less family discouragement and better family communication is associated with a higher likelihood to eat evening family meals and family breakfasts together, and not in front of a television, according to the paper, ‘Family Meal Practices and Weight Talk Between Adult Weight Management and Weight Loss Surgery Patients and Their Children’, published in the Journal of Nutrition Education and Behavior.

SOPHIA consortium: improving risk assessment of comorbidities and treatment for people with obesity

Twenty-nine leading international partners have joined forces to establish a research consortium Stratification of Obese Phenotypes to Optimize Future Obesity Therapy (SOPHIA) with the aim of improving risk assessment of comorbidities and treatment for people with obesity. Obesity complications are common, but predicting who will develop any of the 200 known complications of obesity is extremely difficult. Moreover, there are insufficient predictors for who will respond to obesity treatments.

Fractyl gains FDA IDE approval to begin pivotal study of Revita DMR

Fractyl Laboratories has received approval from the FDA of an Investigational Device Exemption (IDE) to begin a pivotal study of Revita DMR in type 2 diabetes (T2D) patients treated with insulin. This landmark pivotal study, called Revita T2Di, is a prospective, randomised, double-blind, sham-controlled study enrolling 300 patients at up to 35 sites around the world, with approximately 25 sites in the US.

Banded sleeve gastrectomy has better weight loss at four years compared to LSG

Laparoscopic banded sleeve gastrectomy (LBSG) appears to be significantly more effective than laparoscopic sleeve gastrectomy (LSG) in terms of weight loss in the midterm follow-up, according to researchers from Italy. The randomised study, ‘Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study’, published in the Journal of Obesity, sought to compare LBSG and LSG over a four-year follow-up.

Childhood obesity rates could increase if schools stay closed

The childhood obesity rate may increase 2.4% or 1.27 million children if school closures to prevent the spread of the coronavirus continue into December, according to the study, ‘Projecting the impact of COVID-19 pandemic on childhood obesity in the U.S.: A microsimulation model’, published in the Journal of Sport and Health Science.

Scientists identify ALK gene that may prevent weight gain

Researchers from the University of British Columbia, Canada, believe they have identified a gene that may prevent weight gain, after using a genetic database of more than 47,000 people in Estonia. The gene is linked to thinness and may play a role in resisting weight gain in these metabolically healthy thin people. Deleting the gene resulted in thinner flies and mice, and that the expression of it in the brain may be involved in regulating energy expenditure.

Anti-obesity medications prevent weight regain in RYGB patients

Boston University School of Medicine researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery. The retrospective study paper, 'The Mitigating Effect of Phentermine and Topiramate on Weight Regain after Roux-en-Y Gastric Bypass Surgery', was published in Obesity.

BOMSS calls on UK government to take urgent action to tackle severe obesity

The British Obesity and Metabolic Surgery Society (BOMSS) has written a letter to British Prime Minister, Boris Johnson, welcoming his plans to launch an anti-obesity strategy and urging him to take urgent action to help the NHS to rapidly introduce effective treatment for people with severe obesity.