COVID-19 may trigger onset of diabetes in healthy people

A letter published in the New England Journal of Medicine, and signed by an international group of 17 leading diabetes experts from the multidisciplinary Diabetes Surgery Summit (DSS), has announced the creation of the CoviDiab project. The CoviDiab project is a collaborative international research initiative that has established a Global Registry to collect new cases of diabetes in patients with COVID-19.

Bariatric News - Returning to Bariatric Surgery survey

Dear reader,

Bariatric News is carrying out a survey of Bariatric and Metabolic Surgeons and Allied Healthcare Professionals to collect and report their views on safely returning to bariatric surgery post COVID-19. 

The survey is anonymous and only takes 2 minutes (13 questions) to complete. The outcomes will be published on in the coming weeks. 

Please click here to access the survey.

Crick researchers uncover secrets behind healthy gut maintenance

Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut.

Cells in the lining of the small intestine are replaced around every five days, the quickest rate for any organ in the body. This fast replacement helps the lining cope with the damage it suffers as a result of breaking down food and absorbing nutrients.

liraglutide treatment for diabetes does not cause pancreatitis

Researchers from the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, investigating the effect of a Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans, have reported that increased markers are not a sign of pancreatitis, but that GLP‐1RAs is creating a new normal state, a so-called new steady state, in the patients.

RYGB more effective than BMT for achieving albuminuria remission in patients with T2DM and obesity

Roux-en-Y gastric bypass surgery (RYGB) is more effective than best medical treatment (BMT) for achieving remission of albuminuria and stage G1 to G3 and A2 to A3 CKD in patients with type 2 diabetes and obesity at 24 months, according to the results of a randomised clinical trial by researchers from Brazil.

BMI is inconsistent when measuring obesity for Maori and Pacific people

Body mass index is likely to be an inconsistent measure of obesity in Māori and Pacific patients, according to a study by University of Otago researchers.  Specifically, researchers from HeartOtago - a group of cardiovascular researchers and clinicians located at the University and Dunedin Hospital - looked at epicardial adipose tissue (EAT), a special form of fat surrounding the heart which has been linked to increased risk of heart attacks and disturbances in heart rhythm.

Sleeve gastrectomy might be preferable for bariatric patients at risk of bone fractures

Sleeve gastrectomy (SG) might be the best option for weight loss in patients in whom fractures could be a concern, compared with Roux-en-Y Gastric Bypass (RYGB) which maybe be associated with an increased fracture risk, according to researchers from Rush University Medical Center, Chicago, IL.

PREDICT-1 study: inflammation after meals varies dramatically among healthy adults

Participants had a wide range of metabolic responses after eating in apparently healthy adults and that inflammation triggered by the food they consumed varied up to ten-fold, according to researchers led by King's College London after they published the first published results from PREDICT, the largest ongoing nutritional study of its kind. The results were featured in the paper, ‘Human postprandial responses to food and potential for precision nutrition’, published in Nature Medicine and presented at the American Society of Nutrition 2020.

Fat burning molecule that has implications for treatment of obesity

Researchers have identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.

Adipocytes cell's immune response makes obesity worse

Scientists at Cincinnati Children's and the University of Cincinnati College of Medicine have outlined the details of new cellular process that shows how adipocytes’ (fat calls) immune response worsens obesity. The team reports that type I interferons, a class of substances produced by immune cells also are produced by fat cells called adipocytes. These interferons drive a constant low-level, chronic immune response that amplifies "vigour” to a cycle of inflammation within white adipose tissue (WAT).

FDA approves United Imaging’ uMR OMEGA MRI for bariatric patients

United Imaging has received FDA clearance of the uMR OMEGA magnetic resonance imaging (MRI) scanner, the world’s first ultra-wide 75-cm bore. With the widest bore in the market at any field strength, uMR OMEGA provides a unique, patient-centric experience designed to accommodate a wide range of patients. With a 75-cm bore and 680lbs table capacity, uMR OMEGA addresses evolving demographics in the US community, not only improving patient comfort for all but creating, for the first time, an MRI for bariatric patients.

Nutrient sensing capacity of Enterochromaffin cells change after high-fat diet-induced obesity and metabolic disease

Investigators at Flinders University  have found that the nutrient sensing capacity of Enterochromaffin (EC) cells, which line the gastrointestinal tract and are the source of almost all serotonin in the body, change in mice under the influence of high-fat diet-induced obesity and metabolic disease.

Pseudogynecomastia: Flap technique retains nipple colour in men after significant weight loss

Surgeons at UT Southwestern Medical Center have pioneered a new technique that prevents nipple discoloration and preserves shape in men who undergo breast reduction surgery following significant weight loss. The procedure, described in the paper, ‘An Alternative Treatment of Pseudogynecomastia in Male Patients After Massive Weight Loss’, was published in the Aesthetic Surgery Journal Open Forum.

Families with better communication improve their eating habits

Less family discouragement and better family communication is associated with a higher likelihood to eat evening family meals and family breakfasts together, and not in front of a television, according to the paper, ‘Family Meal Practices and Weight Talk Between Adult Weight Management and Weight Loss Surgery Patients and Their Children’, published in the Journal of Nutrition Education and Behavior.

SOPHIA consortium: improving risk assessment of comorbidities and treatment for people with obesity

Twenty-nine leading international partners have joined forces to establish a research consortium Stratification of Obese Phenotypes to Optimize Future Obesity Therapy (SOPHIA) with the aim of improving risk assessment of comorbidities and treatment for people with obesity. Obesity complications are common, but predicting who will develop any of the 200 known complications of obesity is extremely difficult. Moreover, there are insufficient predictors for who will respond to obesity treatments.

Fractyl gains FDA IDE approval to begin pivotal study of Revita DMR

Fractyl Laboratories has received approval from the FDA of an Investigational Device Exemption (IDE) to begin a pivotal study of Revita DMR in type 2 diabetes (T2D) patients treated with insulin. This landmark pivotal study, called Revita T2Di, is a prospective, randomised, double-blind, sham-controlled study enrolling 300 patients at up to 35 sites around the world, with approximately 25 sites in the US.

Banded sleeve gastrectomy has better weight loss at four years compared to LSG

Laparoscopic banded sleeve gastrectomy (LBSG) appears to be significantly more effective than laparoscopic sleeve gastrectomy (LSG) in terms of weight loss in the midterm follow-up, according to researchers from Italy. The randomised study, ‘Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study’, published in the Journal of Obesity, sought to compare LBSG and LSG over a four-year follow-up.