Genetic predisposition to increased weight causally protective for breast and prostate cancer

Researchers from Brunel University London found that increasing weight is causally protective for breast and prostate cancer, according to researcher presented by Dr Hasnat Amin, a doctoral student at Brunel University London, who presented the results of the study at the American Society of Human Genetics 2020 Virtual Meeting.

Higher vitamin D levels in first year of life fight against obesity in adolescence

Low levels of vitamin D during the first year of life are inversely associated with metabolic syndrome in adolescence - which is closely linked to obesity - according researchers at the University of Michigan. They reported that serum 25-hydroxyvitamin D [25(OH)D] at aged one is inversely associated with childhood BMI-for-age z-score (BMIZ), percentage body fat at age 16/17 years and a metabolic syndrome (MetS) score at age 16/17 years.

Health disparities in childhood obesity and access to bariatric surgery

Although adolescents with obesity are choosing bariatric surgery as a way to lose a significant amount of weight, many of those with severe obesity, especially Hispanic and Black adolescents, are not being offered that treatment option. There findings were reported in a retrospective study, ‘Disparity Between United States Adolescent Class II and III Obesity Trends and Bariatric Surgery Utilization, 2015-2018’, published in Annals of Surgery by researchers at The University of Texas Health Science Center at Houston (UTHealth).

MicroRNA contributes to obesity, insulin resistance and T2DM

UC Berkeley Nutritional Sciences investigators have discovered that a microRNA (non-coding RNA that prevent genes from making proteins) is associated with energy storage and metabolic diseases such as obesity, insulin resistance and type 2 diabetes. The findings, ‘A MicroRNA Linking Human Positive Selection and Metabolic Disorders’, were published in Cell.

Bariatric patients have lower risk of additional myocardial infarctions

Swedish researchers at Karolinska Institutet and Danderyd Hospital, examining the risk of additional myocardial infarctions and early death in patients with severe obesity who undergo metabolic surgery following a myocardial event, have reported a lower risk of additional myocardial infarctions and improved survival that cannot be simply attributed to the loss of weight in this group of patients.

ObesityWeek 2020 goes interactive

Scientists from across the globe will present the latest research in obesity  science and medicine and related topics at the 38th Annual Meeting of The Obesity Society (TOS) at ObesityWeek Interactive. This online event will take place November 2–6, 2020 at On-demand materials and other elements of the interactive conference will remain available online through to December 31, 2020.

Patients and HCPs need to improve knowledge of obesity

Researchers from Israel have reported both patients with obesity and healthcare professionals (HCPs) need to improve awareness regarding the physiologic basis and clinical management of obesity. Specifically, they noted that physicians need to improve how to approach weight and weight management discussions during patient consultations.

Bariatric surgery, body image and depression

Body image is a mediating factor of depression in subgroup of laparoscopic sleeve gastrectomy (LSG) patients with poor psychological outcome, report researchers from the Medical University Hospital Tübingen, Tübingen and the University of Duisburg-Essen, Essen, Germany. They noted that the current preparation and aftercare regimes for patients that undergo bariatric surgery often focus on nutrition and physical activity, but hardly target psychological components, and interventions to improve body image should be incorporated into aftercare regimes.

The relationship between mucus and gut microbiome

Researchers from Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK, have redefined how the so-called gut microbiome operates and how our bodies coexist with some of the 100 trillion bacteria that make it up. The findings, ‘Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota’, were published in the journal Science, and could lead to new therapies for inflammatory bowel disease and people who've had portions of their bowels removed due to conditions like colon cancer and ulcerative colitis.

Mismatch hypothesis supports link of obesity and disease to dietary changes

A study by Princeton University and Mpala Research Center, in Kenya, has found evidence for the ‘mismatch’ hypothesis when they found that obesity, diabetes and cardiovascular illnesses increased among whose diet changed from animal-based to carbohydrate-based. The mismatch hypothesis argues that our bodies have evolved and adapted to digest the foods that our ancestors ate and that human bodies will struggle and largely fail to metabolise a radically new set of foods.

Pre-bariatric surgery aerobic exercise decreases hospital stay

Undertaking aerobic exercise prior to bariatric surgery in addition to standard medical care decreased the length of hospital stay in patients receiving bariatric surgery, compared to standard medical care alone, according to the outcomes of a small pilot trial by researchers from University of Virginia, Charlottesville, VA. The outcomes were featured in the paper, ‘Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial’, published in PLOS One.

Increase access to bariatric surgery for PCOS treatment

Access to bariatric surgery should be increased as part of the main treatment considerations in women with obesity and polycystic ovarian syndrome (PCOS). The paper, ‘A Review of the Impact of Bariatric Surgery in Women With Polycystic Ovary Syndrome’, published in Cureus, led by California Institute of Behavioral Neurosciences & Psychology, Fairfield in the US, also recommends that additional research with better study designs are required in the future to investigate the relationship between PCOS and bariatric surgery.

Vietnamese Americans without obesity 60% more likely to have diabetes

Vietnamese-American adults who did not have obesity were 60% more likely to have diabetes than those without obesity, non-Hispanic, White Americans, after accounting for age, sex, sociodemographic factors, smoking history and exercise level. Overall, only 9% of Vietnamese Americans with diabetes in the study had obesity. In comparison, half of all non-Hispanic White Americans with diabetes had obesity.

Abnormalities in laminin expression associated with Hirschsprung disease

Researchers from Le Bonheur Children's Hospital and the University of Tennessee Health Science Center who are trying to determine the mechanisms underlying abnormal development of the enteric nervous system in Hirschsprung disease, have reported delineating interactions between migrating neural crest cells and the extracellular matrix in a model of Hirschsprung disease using a variety of in vitro and in vivo approaches.

Obesity rates among Irish primary school children deceasing

According to the latest The Childhood Obesity Surveillance Initiative (COSI) in the Republic of Ireland (COSI) survey - carried out as part of the World Health Organization and European Union's effort to measure weight trends in young children - obesity rates in primary school children across Ireland are decreasing. The prevalence of obesity in children aged six to ten has continued to go down year on year.