SOReg: T2DM patients should have bariatric surgery earlier

The latest findings from the annual Scandinavian Obesity Surgery Registry (SOReg) report could challenge existing recommendations and clinical practice for bariatric surgery and type 2 diabetes (T2DM) patients, according to the authors of a summary paper of the report, ‘Bariatric Surgery: There Is a Room for Improvement to Reduce Mortality in Patients with Type 2 Diabetes’, published in Obesity Surgery.

Testosterone therapy results in weight lost and improves metabolic parameters

Males with obesity suffering from hypogonadism who have testosterone injections lost weight and saw improvement in a wide range of other metabolic parameters, according to research led by Dr Farid Saad, Consultant, Medical Affairs Andrology, Bayer AG, Berlin, Germany, and Gulf Medical University School of Medicine, Ajman, UAE, and colleagues. The study was presented at the European and International Congress on Obesity (ECOICO 2020).

Hospital-diagnosed overweight or obesity for patients over 40 years increases mortality risk

Individuals whose overweight or obesity is diagnosed in hospital are 60% more likely to die compared to the general population, according to a nationwide Danish study that followed over 1.9 million people for up to 40 years, presented at The European and International Congress on Obesity. The risk of dying was highest within the first year of diagnosis but remained markedly higher for individuals with hospital-diagnosed overweight or obesity over the whole study period.

Immunology disturbances, COVID and obesity may explain increased risk of mortality

Data presented in a special COVID-19 session at the European and International Congress on Obesity (ECOICO 2020) suggests that there are overlaps between the immunological disturbances found in both COVID-19 disease and patients with obesity, which could explain the increased disease severity and mortality risk faced by patients with obesity and COVID-19. Since fat mass generally increases with ageing, this might also partly explain the increased death risk in older patients.

Obesity: The importance of the language used by healthcare professionals

An online survey of nearly 3,000 UK adults suggests that people would prefer health professionals to use the words "weight", "unhealthy weight", and "overweight" when discussing weight status, and reveals parents' desire to avoid their children being referred to as "fat", "extra-large", or "plus size".

People struggled to manage their weight during COVID-19 lockdown

More than half of adults have found it difficult to manage their weight during the COVID-19 lockdown, according to the results of an online survey involving over 800 UK adults, presented at The European and International Congress on Obesity. Most of the respondents said their difficulties stemmed from increased snacking, not exercising as much as usual, increased anxiety or stress and not being able get hold of healthier food.

Weight shaming still commonplace in US and UK

Americans are less likely to blame people with obesity for their condition and are more likely to believe that obesity has a medical explanation now than three years ago, according to the results of two online surveys involving more than 6,000 UK and US adults. The outcomes were presented at the European and International Congress on Obesity (ECOICO 2020).

Clear association between COVID-19 disease severity and obesity

There is a clear relationship between obesity and the severity of COVID-19 disease, according to research presented by François Pattou, Professor of Surgery at the Faculty of Medicine of the University of Lille, and head of the Department of General and Endocrine Surgery at Lille University Hospital, France, at this year's European and International Congress on Obesity.

HUMBLE brown-fat-like cells hold promise for obesity and diabetes

Scientists at Joslin Diabetes Center have delivered a proof of concept for a novel cell-based therapy for obesity that would by transplanting human brown-like (HUMBLE) fat cells, human white fat cells that have been genetically modified to become similar to heat-generating brown fat cells. The finding were reported in the paper, ‘CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice’, published in Science Translational Medicine.

Faecal microbiome plus dieting may limit weight regain

People who consume frozen microbiome capsules derived from their own faeces when dieting may limit their weight regain, according to a study. ‘Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain’, published in Gastroenterology, conducted by a team of researchers led by Israeli researchers at Ben-Gurion University of the Negev (BGU).

Synthetic coating for the GI tract could offer a new strategy to treat diabetes or obesity

Massachusetts Institute of Technology (MIT) researchers have devised a way to apply a temporary synthetic coating to the lining of the small intestine that could be adapted to deliver drugs, aid in digestion or prevent nutrients such as glucose from being absorbed, which could offer a new strategy to treat diabetes or obesity.

Novel combination therapy tethering T2DM drugs increases efficacy

Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than simply concurrently administered. The combination molecule is formed by an elastin-like polypeptide (ELP) linker that forms a gel-like depot when injected under the skin, which slowly dissolves and releases the active drug over time.

COVID-19: Patients with metabolic syndrome 3.4 times more likely to die

Patients hospitalised with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a study by researchers from Tulane University. The study, ‘Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans’, published in the journal Diabetes Care, is the first to look at the impact of metabolic syndrome on outcomes for COVID-19 patients.

Origami-inspired surgical robotics brings technology down to the microscale

A collaboration between Wyss Associate Faculty member, Dr Robert Wood and Robotics Engineer Hiroyuki Suzuki from the Sony Corporation has brought surgical robotics down to the microscale by creating a new, origami-inspired miniature remote centre of motion manipulator (mini-RCM). The robot is the size of a tennis ball, is light weight and successfully performed a difficult mock surgical task. A review of the technology, ‘Origami-inspired miniature manipulator for teleoperated microsurgery’ was published in Nature Machine Intelligence.

IFSO-LAC issues recommendations for the resumption of elective bariatric surgery

The resumption of elective bariatric and metabolic surgery is crucial and must be a priority similar to oncological surgery because it is not only a weight loss operation but also resolves or improves comorbidities and appears to be an immune restorative procedure of obese patients in the medium term, according to recommendations from IFSO’s Latin America Chapter. The paper, ‘COVID-19: IFSO LAC Recommendations for the Resumption of Elective Bariatric Surgery’, was published in Obesity Surgery.

Bariatric patients continue to smoke after surgery

A considerable group of bariatric surgery patients continue smoking after surgery despite advice to quit and temporary quitting before surgery, according to researchers from The Netherlands. The authors noted that this is the first study in bariatric surgery evaluating self-reported smoking behaviour combined with thoughts about the health consequences of smoking cessation and actual health outcomes in current, former and never smokers.

Intensive lifestyle intervention can lower obesity-related cancer risk

Intensive lifestyle intervention (ILI) aimed at weight loss lowered the incidence of obesity-related cancers in adults with overweight or obesity and type 2 diabetes, according to a randomised clinical trial that has examined long-term cancer outcomes in an ILI focused on weight loss by researchers from Johns Hopkins University in Baltimore, MD.