Faecal microbiome plus dieting may limit weight regain

People who consume frozen microbiome capsules derived from their own faeces when dieting may limit their weight regain, according to a study. ‘Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain’, published in Gastroenterology, conducted by a team of researchers led by Israeli researchers at Ben-Gurion University of the Negev (BGU).

Synthetic coating for the GI tract could offer a new strategy to treat diabetes or obesity

Massachusetts Institute of Technology (MIT) researchers have devised a way to apply a temporary synthetic coating to the lining of the small intestine that could be adapted to deliver drugs, aid in digestion or prevent nutrients such as glucose from being absorbed, which could offer a new strategy to treat diabetes or obesity.

COVID-19: Patients with metabolic syndrome 3.4 times more likely to die

Patients hospitalised with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a study by researchers from Tulane University. The study, ‘Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans’, published in the journal Diabetes Care, is the first to look at the impact of metabolic syndrome on outcomes for COVID-19 patients.

Origami-inspired surgical robotics brings technology down to the microscale

A collaboration between Wyss Associate Faculty member, Dr Robert Wood and Robotics Engineer Hiroyuki Suzuki from the Sony Corporation has brought surgical robotics down to the microscale by creating a new, origami-inspired miniature remote centre of motion manipulator (mini-RCM). The robot is the size of a tennis ball, is light weight and successfully performed a difficult mock surgical task. A review of the technology, ‘Origami-inspired miniature manipulator for teleoperated microsurgery’ was published in Nature Machine Intelligence.

IFSO-LAC issues recommendations for the resumption of elective bariatric surgery

The resumption of elective bariatric and metabolic surgery is crucial and must be a priority similar to oncological surgery because it is not only a weight loss operation but also resolves or improves comorbidities and appears to be an immune restorative procedure of obese patients in the medium term, according to recommendations from IFSO’s Latin America Chapter. The paper, ‘COVID-19: IFSO LAC Recommendations for the Resumption of Elective Bariatric Surgery’, was published in Obesity Surgery.

Bariatric patients continue to smoke after surgery

A considerable group of bariatric surgery patients continue smoking after surgery despite advice to quit and temporary quitting before surgery, according to researchers from The Netherlands. The authors noted that this is the first study in bariatric surgery evaluating self-reported smoking behaviour combined with thoughts about the health consequences of smoking cessation and actual health outcomes in current, former and never smokers.

Intensive lifestyle intervention can lower obesity-related cancer risk

Intensive lifestyle intervention (ILI) aimed at weight loss lowered the incidence of obesity-related cancers in adults with overweight or obesity and type 2 diabetes, according to a randomised clinical trial that has examined long-term cancer outcomes in an ILI focused on weight loss by researchers from Johns Hopkins University in Baltimore, MD.

DUSP8 gene influences T2DM risk by impairing brain response

Researchers from the Helmholtz Zentrum München and the German Center for Diabetes Research (DZD) have reported that in men a genetic variant of the gene DUSP8 can increase the risk for type 2 diabetes by impairing the brain’s response to the hormone insulin. The findings were reported in the paper, ‘Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity’, in the Journal of Clinical Investigations.

Major weight loss driver of post-surgical metabolic benefits

Researchers from Washington University School of Medicine in St Louis have suggested that weight loss after bariatric surgery, rather than the surgery itself, drives metabolic improvements such as the remission of diabetes. Their findings were published in the paper, ‘Effect of diet versus gastric bypass on metabolic function in diabetes’, in The New England Journal of Medicine.