People with severe obesity who underwent bariatric surgery maintained significantly more weight loss at five years than those who did not have surgery, according to a Kaiser Permanente study. Although some weight regain was common after surgery, regain to within 5% of baseline was rare, especially in patients who had gastric bypass instead of sleeve gastrectomy.
Researchers generally agree that genetic and gut microbiome composition and activity are important factors in determining who has and who does not have obesity. As interest and understanding of the human microbiome increases, researchers are increasingly looking to the gut for answers that can lead to new, more effective diagnostics and therapies.
Bariatric surgery significantly reduces colorectal cancer (CRC) risk in patients with obesity to the extent that they share the same risk of colorectal cancer as the general population, according to researchers from Université Côte d’Azur, Nice, France. However, for patients with obesity who do not undergo bariatric surgery, the risk is 34% above that of the general population.
Weight loss should not be the primary motivation behind healthy lifestyle changes, according to researchers from the University of Alberta, Canada, who claim that there is a growing body of research showing that upwards of 95 percent of those who achieve any sort of meaningful weight loss will pack it back on, and then some, within a couple of years.
Researchers at the University of Campinas (UNICAMP) in São Paulo State, Brazil, have developed a computer program that analyses molecules in blood plasma to search for biomarkers that identify individuals who are at risk of becoming overweight and developing obesity-related diseases. The project was conducted in Brazil with funding from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) .