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Gene associated with obesity and T2DM cells fat regulation

Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts (HNRCA) have found one clue as to why weight gain cause metabolic problems that can lead to heart disease and diabetes in some individuals, but not others: a gene associated with obesity and development of type 2 diabetes, they discovered, is also connected to how cells regulate fat at the cellular level.

How nursing homes accommodate residents with obesity

About 30 percent of nursing home residents are obese and that can complicate their care. The facility may need to buy them special wheelchairs or motorised lifts. Nursing aides may struggle to help them shower. And doctors may grapple with how or even whether to restrict their diets. West Virginia University researcher, Nicholas Castle is part of a team investigating how nursing homes can best achieve the healthcare needs residents with obesity.

Metabolic surgery superior to drug treatment in patients with obesity

Metabolic or bariatric surgery was significantly more effective than medical management in treating type 2 diabetes in patients with milder forms of obesity, according to new research presented at an American Society for Metabolic and Bariatric Surgery (ASMBS) national clinical symposium on obesity prevention, treatment and research.

New mutation in leptin gene may explain excess of body fat

Researchers at Texas Biomedical Research Institute, San Antonio, TX, have discovered a new mutation in the gene that regulates the key hormone suppressing hunger called leptin. This new mutation could help researchers understand why people develop excess of body fat. The research is aimed at helping tackle metabolic disorders like cardiovascular disease and diabetes which are fuelled by obesity and impact millions of people around the world.

Leptin signal pathway for obesity-related fatty liver disease

A research group from the Medical University of Vienna have reported that leptin stimulates the liver to export lipids and reduce the fat production in the liver, due to the activation of neurons in the brain stem. These findings provide new approaches for the fight against non-alcoholic fatty liver disease, which often occurs in connection with obesity.

Brain energy expenditure during childhood linked to obesity risk

A new paper has proposed that variation in the energy needs of brain development across children in terms of the timing, intensity and duration of energy use could influence patterns of energy expenditure and weight gain.

Plasma leptin concentrations are not limited to the brain

Yale researchers have offered insight into leptin - a hormone that plays a key role in appetite, overeating and obesity - heir findings advance knowledge about leptin and weight gain, and also suggest a potential strategy for developing future weight-loss treatments, they said.

Overweight and adolescents with obesity have similar heart risk

A study performed in Brazil by researchers from São Paulo State University (UNESP) suggests that overweight adolescents and adolescents with obesity have similar increased risks of developing heart disorders. The results of cardiovascular fitness tests with volunteers aged 10 to 17 were similar in both groups.

New US diabetes cases fall as obesity rises

The number of new diabetes cases among US adults keeps falling, even as obesity rates climb, according to research led by Dr Stephen Benoit of the Centers for Disease Control and Prevention. The new federal data revealed the number of new diabetes diagnoses fell to about 1.3 million in 2017, down from 1.7 million in 2009, a decline that has been going on for close to a decade. However, health officials are not celebrating.

Genetic switch controls conversion of bad to good fat

Researchers at University of Utah Health have identified TLE3, a genetic switch that stops the conversion of white fat into thermogenic varieties. Fat cells come in three varieties: white fat, the most common variety, is stored fat associated with metabolic disorders, like diabetes and obesity – whereas Brown and beige fat contain more mitochondria, the energy centres of the cell, allowing these varieties to burn fuel more efficiently. Brown fat is activated in cold conditions and burned to create heat.

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