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type 2 diabetes mellitus

EarlyBird results shows why children are at risk of future T2DM

Researchers at the University of Plymouth and Nestlé have revealed new insights into the factors that predispose children to developing type 2 diabetes in adult life. The EarlyBird study followed 300 healthy children in Plymouth, UK, from five years of age to early adulthood to explore how the metabolism changes during growth for 15 years and determine who would become at risk of developing type 2 diabetes, and why.

Blood lipid profile can predict risk of T2DM better than obesity

Using lipidomics, a technique that measures the composition of blood lipids at a molecular level, and machine learning, researchers at Lund University, Sweden, have identified a blood lipid profile that improves the possibility to assess, several years in advance, the risk of developing type 2 diabetes. The blood lipid profile can also be linked to a certain diet and degree of physical activity.

Self-renewing stem cells show potential in combating diabetes

Stem cells could help turn the tide against diabetes, but more research is needed to better control their differentiation and insulin-producing properties, according to investigators from A*STAR's Institute of Molecular and Cell Biology (IMCB), Singapore. Led by Dr Adrian Teo, a Principal Investigator at A*STAR, the research team have proposed that by harnessing the power of stem cells to self-renew and can be differentiated into a variety of cell types, including pancreatic beta cells.

Obesity linked to a six-fold increased risk of T2DM

Obesity is linked to a nearly 6-fold increased risk of developing type 2 diabetes mellitus (T2DM), with high genetic risk and unfavourable lifestyle also increasing risk but to a much lesser extent, according to research presented at the Annual Meeting of the European Association for the Study of Diabetes in Barcelona, Spain by Hermina Jakupovic, University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark, and colleagues.

IL-36 cytokines proteins associated with better T2DM control

Scientists from the School of Medicine, Trinity College Dublin, have discovered a family of proteins that are associated with lower blood sugar levels among obese patients with type 2 diabetes. The study showed that patients with type 2 diabetes who have high levels of the protein, IL-36 cytokines, were found to have lower blood sugar levels, implying that those proteins are associated with better control of the patient's blood sugar levels and their disease.

Short stature is associated with higher risk of T2DM

Short stature is associated with a higher risk of type 2 diabetes and tall stature is associated with a lower risk, with each 10cm difference in height associated with a 41% decreased risk of diabetes in men and a 33% decreased risk in women, according to researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke, Germany.

Three POCs to become early adopters of the Low Carb Program

Three primary care organisations (POCs) in the UK, have been announced as joint winners of a competition to enable healthcare professionals to offer free access to an award-winning behaviour change platform, the Low Carb Program, for a select group of their patients living with Type 2 diabetes. The organisations were named as: Frome Medical Practice (on behalf of Your Health & Wellbeing collaboration of three Primary Care Networks) in Frome, Somerset; Park Medical Centre in London and Freshwell Health Centre in Braintree, Essex.

Changes to mitochondria drive chronic inflammation linked to T2DM

The underlying causes of inflammation in obesity and type 2 diabetes mellitus (T2DM) are multifactorial and complex, which has hampered efforts to develop treatments to prevent complications from a disease that is the third leading cause of death in the US. Researchers at the University of Kentucky have reported that changes to mitochondria drive chronic inflammation from cells exposed to certain types of fats, shattering the prevailing assumption that glucose was the culprit.

Researchers investigate autophagy’s role in metabolic disease

Researchers at the University of Florida are investigating how autophagy - the body's way of cleaning out damaged cells, in order to regenerate newer, healthier cells - plays a role in metabolic diseases such as obesity and type 2 diabetes.

Vitamin D supplementation may slow diabetes progression

Vitamin D supplementation may slow the progression of type 2 diabetes in newly diagnosed patients and those with pre-diabetes, suggesting that high-dose supplementation of vitamin D can improve glucose metabolism to help prevent the development and progression of diabetes.

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