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cardiovascular disease

Metabolically 'healthy' obesity linked to higher risk of CVD

Women who have obesity and who have been metabolically ‘healthy’ for decades are still at higher risk of developing cardiovascular disease (CVD) compared to metabolically healthy women of normal weight, according to an observational study that followed over 90000 American women for up to 30 years.

Obesity paradox not found when measuring new cases of CVD

A study by NYU College of Global Public Health and the University of Michigan has reported that the so-called ‘obesity paradox’ is not present among people with new cases of cardiovascular disease (CVD). Although obesity is a well-known risk factor for getting cardiovascular disease, a controversial body of research suggests that obesity may actually be associated with improved survival among people who have cardiovascular disease.

Novel therapy to lessen risk of obesity-linked disease

A multi-institutional scientific team led by Cincinnati Children's Hospital Medical Center has discovered a previously unknown molecular link in the body that drives obesity and inflammation. Obesity and metabolic inflammation are linked to cardiovascular disease, type 2 diabetes, fatty liver disease and several cancers.

‘Healthy' obese people at higher risk of CVD events

Research presented at this year's European Congress on Obesity (ECO) in Porto, Portugal, has revealed that so called 'metabolically healthy' obese people are still at higher risk of cardiovascular disease (CVD) events, such as heart failure or stroke than normal weight people. The study, which included 3.5 million people, was led by Dr Rishi Caleyachetty and colleagues at The Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, UK.

Vit D deficiency indicates heart disease in overweight teens

In overweight and obese children and adolescents, vitamin D deficiency is associated with early markers of cardiovascular disease, according to a study presented at ENDO 2017, the annual scientific meeting of the Endocrine Society, in Orlando.

Leptin plays role in cardio disease in obesity

Researchers led by Dr Eric Belin de Chantemele, a physiologist in the Department of Physiology at the Medical College of Georgia at Georgia Regents University, have reported that leptin acts directly on adrenal glomerulosa cells to increase CYP11B2 expression and enhance aldosterone production via calcium-dependent mechanisms. Furthermore, leptin-mediated aldosterone secretion contributes to cardiovascular disease by promoting endothelial dysfunction and the expression of pro-fibrotic markers in the heart.

Surgery has “impressive” effect on cardiac factors

The largest ever systematic review of studies into the relationship between bariatric surgery and cardiovascular function has concluded that surgery has an “impressive” effect on cardiac risk factors, and that no pharmacological treatment has shown a similar effect over such short time periods.

Weight loss does not lower heart risk from T2DM

Intensive diet and exercise programme resulting in weight loss does not reduce cardiovascular events in type 2 diabetics, according to a the Look AHEAD (Action for Health in Diabetes) study.

Although the intervention did not reduce cardiovascular events, Look AHEAD reported other important health benefits of the lifestyle intervention, including decreasing sleep apnoea, reducing the need for diabetes medications, helping to maintain physical mobility, and improving quality of life.

Bypass more beneficial than non-surgical treatment

A six-year study assessing the association of Roux-en-Y gastric bypass with weight loss, diabetes mellitus and other health risks, has concluded that it is more beneficial than non-surgical treatment.

Excess visceral fat increases T2DM risk

People with excess visceral fat have an increased risk for the development of type 2 diabetes, according to a new study by researchers at UT Southwestern Medical Center, Texas.

“Among obese individuals, it is not necessarily how much fat a person has, but rather where the fat is located on a person that leads to diabetes,” said Dr James de Lemos, professor of internal medicine at UT Southwestern, and senior author of the study.

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