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Weight loss prior to surgery may not be safe for all patients

Weight loss prior to metabolic and bariatric surgery may not be necessary for all patients and unsafe weight loss prior to surgery may compromise nutrition status and lead to increased infection rates, according to researchers from the University of Pennsylvania.

Risk of obesity influenced by changes in genes

A child's risk of obesity as they grow up can be influenced by modifications to their DNA prior to birth, a new University of Southampton study has shown. These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence. One of the main epigenetic modifications is DNA methylation, which plays a key role in the development of the embryo and the formation of different cell types, regulating when and where genes are switched on.

Sutures more effective than clips for mesenteric defect closures

Closure of the mesenteric defects using either non-absorbable metal clips or non-absorbable running sutures is a safe and effective measure to reduce the risk for small bowel obstruction after laparoscopic gastric bypass surgery, according to researchers from the Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. However, they noted that sutures appear slightly more effective and should remain gold standard for mesenteric defects closure.

Women with obesity linked with increased risk of early-onset CRC

Women who are overweight or have obesity have up to twice the risk of developing colorectal cancer (CRC) before age 50 as women who have what is considered a ‘normal’ BMI, according to new research led by Washington University School of Medicine in St Louis.

Obstructive sleep apnoea associated with higher risk of gout

People with obstructive sleep apnoea (OSA) have a higher risk of developing gout, even beyond the first years after being diagnosed with the sleep disorder, according to researchers from Keele University, UK. OSA is associated with a range of serious comorbidities, and it has previously been shown that people with OSA have a higher risk of developing gout in the first year after diagnosis.

Surgery may reduce hormone-related cancer, but increase CRC risk

An analysis examining the impact of bariatric surgery on cancer has indicated that bariatric surgery may affect an individual's risk of developing cancer, although the researchers note that additional studies are needed to understand the biological mechanisms behind these findings.

Bariatric surgery is associated with decline in risk of melanoma

Bariatric surgery is associated with a 61% fall in the risk of developing malignant melanoma skin cancer, and a 42% drop in the risk of skin cancer in general, according to a study by researchers from the University of Gothenburg, Sweden, presented at the European Congress on Obesity in Vienna, Austria.

Middle-aged women who gain weight increase cancer risk

Researchers from Norway have reported that putting no weight increases the risk of cancer for middle-aged women.  The results of the study were presented at the European Congress on Obesity, in Vienna, Austria. The study, which tracked more than 137,000 Norwegian women for 18 years, found that the odds of developing certain cancers rose as waistlines expanded.

Irish researchers report T2DM can be reversed with 15% weight loss

The Irish Society for Clinical Nutrition & Metabolism (IrSPEN) is advising people living with type 2 diabetes and obesity that they can reverse or put their diabetes into remission, if they can lose 15% of their body weight. This even applies to the people who are on insulin, who have poor diabetes control and is independent of the starting BMI making this relevant to any person living with type 2 diabetes who has a BMI over 30.

Middle age T2DM risk reduced if healthy weight is maintained

Young adults suffering from obesity who lose enough weight to no longer be considered obese before early middle age reduce their risk of developing diabetes by nearly 70 percent compared to those who remain obese over the same life interval, according to a study by researchers from the Boston University School of Public Health.

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