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Metformin may help patients maintain weight loss long-term

In the Diabetes Prevention Program (DPP) clinical trial and its long-term follow-up study, among the persons who lost at least 5 percent of their body weight during the first year, long-term maintenance of weight loss was more likely if they had been assigned to treatment with metformin than with placebo or lifestyle intervention. Being older and losing a greater amount of weight in the first year were the most consistent predictors of lasting weight loss.

Gelesis data shows hydrogel restores gut barrier function

Gelesis has announced clinical data from its pivotal Gelesis Loss of Weight (GLOW) study suggesting that elevated fasting plasma glucose could be a useful and unique predictor to identify individuals who have higher adjusted odds to achieve significant weight loss with Gelesis100.

Bariatric embolization shows promise as a treatment for obesity

Although bariatric embolization is unlikely to promote weight loss as effectively as bariatric surgery, it is at least as effective as some pharmacotherapies (ie, liraglutide, orlistat, lorcaserin), which induce mean weight loss of 2%–9% (28), according to researchers from the Bariatric Embolization of Arteries for the Treatment of Obesity (BEAT Obesity) trial, who assessed the procedure's effects on 20 severely obese participants over the course of one year.

Exercise is more critical than diet to maintain weight loss

A study from the University of Colorado Anschutz Health and Wellness Center (AHWC) at the CU Anschutz Medical Campus has revealed physical activity does more to maintain substantial weight loss than diet. The findings reveal that successful weight-loss maintainers rely on physical activity to remain in energy balance (rather than chronic restriction of dietary intake) to avoid weight regain.

Testosterone can help men with hypogonadism lose weight

Long-term testosterone therapy can help men with hypogonadism lose weight and maintain their weight loss, according to researchers from Germany and the US, who reported ten-year results of an ongoing study presented at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, LA.

Patients with obesity can decrease frequency of migraines by losing weight

For migraine sufferers with obesity, losing weight can decrease headaches and improve quality of life, according to researchers from Italy and the United States. The results of their meta-analysis, ‘SAT-108. Effects of Bariatric and Non-Bariatric Weight Loss on Migraine Headache in Obesity. A Systematic Review and Meta-Analysis’, were presented at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, LA.

Oral semaglutide vs sitagliptin has superior reductions in HbA1c and weight

Oral semaglutide 7mg and 14mg demonstrated superior HbA1c and body weight reductions compared to Januvia (sitagliptin 100mg), although non-inferiority for oral semaglutide 3mg for HbA1c reductions at 26 weeks was not confirmed.

Implantable self-powered stimulation device aids weight loss

A new battery-free, easily implantable weight-loss devices developed by engineers at the University of Wisconsin-Madison could offer a promising new weapon for battling the bulge. Measuring less than 1cm across, the tiny devices are safe for use in the body and implantable via a minimally invasive procedure, generate gentle electric pulses from the stomach's natural churning motions and deliver them to the vagus nerve, which links the brain and the stomach. That gentle stimulation dupes the brain into thinking that the stomach is full after only a few nibbles of food.

Psychosocial impact of weight loss following bariatric surgery

Patients considering bariatric surgery may benefit from anticipatory guidance regarding possible complex changes in self-perception and inter-personal relationships following surgery, according to a study by researchers from the University of Michigan. These changes may be proximal mediators of commonly assessed mental health outcomes such as depression, therefore, post-surgical longitudinal monitoring should include evaluation for adverse psychosocial events.

SG results in weight loss and co-morbidity resolution up to ten years

Sleeve gastrectomy (SG) results sustained weight loss (WL) and co-morbidity resolution up to ten years post-operatively and although a notable portion of patients experience weight regain (WR), mean percent weight loss (%WL) exceeds 30%, translating in adequate weight loss also in the long term, according to researchers from Sapienza University of Rome, Rome, Italy.

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