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type 2 diabetes

Using microRNA to detect early signs of type 2 diabetes in teens

Researchers know that exosomes, tiny nanoparticles released from fat cells, travel through the bloodstream and body, regulating a variety of processes, from growth and development to metabolism. The exosomes are important in lean, healthy individuals in maintaining homeostasis, but when fat gets 'sick' - the most common reason for this is too much weight gain - it can change its phenotype, becoming inflammatory, and disrupts how our organs function, from how our skeletal muscle and liver metabolise sugar to how our blood vessels process cholesterol.

Early bariatric surgery may resolve comorbidities

Despite similar weight loss, teens who had gastric bypass surgery were significantly more likely to have remission of both type 2 diabetes and high blood pressure, compared to adults who had the same procedure. Results are from an NIH-funded study comparing outcomes in the two groups five years after surgery. Previously, no treatment has shown longer-term effectiveness at reversing type 2 diabetes in youth, which tends to advance more quickly than in adults.

Revita DMR can benefit both NAFLD, NASH and type 2 diabetes

Fractyl Laboratories has announced new clinical data showing its same-day therapeutic procedure - Revita Duodenal Mucosal Resurfacing (DMR) procedure - can generate significant improvements in both nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and type 2 diabetes (T2DM) in people with both conditions. The data was presented at The International Liver Congress, the EASL annual meeting, in Vienna, Austria.

DiaRem extended to predict time for diabetic remission after surgery

Ben-Gurion University of the Negev (BGU) researchers have improved a standard bariatric surgery clinical scoring system (DiaRem) to extend the prediction time for diabetic remission following bariatric surgery. The DiaRem score, which includes a patient's age, BMI, diabetes indicators and treatments, is used to predict the probability of remission of type 2 diabetes after Roux-en-Y gastric bypass (RYGB) surgery.

Unlocking the barriers to obesity and type 2 diabetes treatment

The Johnson and Johnson Institute, the educational arm of Johnson & Johnson, is pleased to announce a series of innovative e-learning programmes in which leading Key Opinion Leaders will not only address the barriers to obesity and type 2 diabetes treatment, but also discuss in detail how to unlock them. During the two remaining webinars, the faculty will demonstrate insightful aspects of a specific barrier and present different approaches on ways of overcoming it.

Surgery reduces microvascular complications of T2DM

Compared with usual care, bariatric surgery was associated with half the incidence of microvascular disease at 5 years for adults with type 2 diabetes mellitus (T2DM), according to researchers from Kaiser Permanente Washington Health Research Institute. The findings add to a growing body of evidence suggesting that bariatric surgery not only improves glucose, blood pressure, and lipid control, but is likely to reduce macrovascular and microvascular complications, as well as improve survival in patients with severe obesity and T2DM.

Unlocking the barriers to obesity and type 2 diabetes treatment

The Johnson and Johnson Institute, the educational arm of Johnson & Johnson, is pleased to announce a series of innovative e-learning programmes in which leading Key Opinion Leaders will not only address the barriers to obesity and type 2 diabetes treatment, but also discuss in detail how to unlock them. During three webinars the faculty will demonstrate insightful aspects of a specific barrier and present different approaches on ways of overcoming it.

Gene therapy resolves type 2 diabetes and obesity in mice

Researchers from the Autonomous University of Barcelona (UAB), led by Professor Fatima Bosch, has managed to cure obesity and type 2 diabetes in mice using gene therapy. A single administration of an adeno-associated viral vector (AAV) carrying the FGF21 (Fibroblast Growth Factor 21) gene, resulted in genetic manipulation of the liver, adipose tissue or skeletal muscle to continuously produce the FGF21 protein. This protein is a hormone secreted naturally by several organs that acts on many tissues for the maintenance of correct energy metabolism.

Study states there should be five types of diabetes

There should be a reclassification of diabetes that would allow healthcare professionals to predict the risk of serious complications and provide treatment suggestions, according to researchers at Lund University in Sweden, and this would include type 2 diabetes consisting of several subgroups. These are the first outcomes from the All New Diabetics In Scania (ANDIS), a study covering all newly diagnosed diabetics in southern Sweden.

Study reveals a very low-calorie diet can reverse T2DM

A study led by researchers from Yale University has described how a very low-calorie diet can rapidly reverse type 2 diabetes in animal models. If confirmed in people, the insight provides potential new drug targets for treating this common chronic disease.  The study, ‘Mechanisms by which a Very Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes,’ was published in Cell Metabolism.

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