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FTO gene variation linked to weight gain and obesity in children

Researchers from Columbia University Irving Medical Center have discovered that children who do not have obesity, but who are at risk for the chronic disease due to a common genetic variant eat more. Led by Dr Michael Rosenbaum,of Columbia University Irving Medical Center's Department of Pediatrics Division of Molecular Genetics, he and colleagues explained that many existing studies of children at risk for increased adiposity include those who already have obesity.

How the brain influences our eating habits and weight gain

Two separate teams of researchers have identified how genes involved in neural development can affect body weight and how brain cells involved in memory play an important role after a meal in reducing future eating behaviour. The first team – led by investigators at the University of Cambridge and Children's Hospital Los Angeles (CHLA) have pinpointed a set of molecules that wire the body weight centre of the brain.

Neuroinflammation protects women from weight gain

A research team at the University of California, Riverside, has found that only male mice experienced neuroinflammation or activation of the immune system's response in the brain, after being fed a high-fat diet. While females were unaffected, males showed low testosterone and reduced sperm count, in addition to neuroinflammation. The study results, 'Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice,' were published in Frontiers in Immunology

People with severe obesity have lonely and prolonged struggle

The majority of people with severe obesity have a lonely and prolonged struggle with their weight, according to the latest paper form the Swedish Obese Subjects (SOS) study, which focused on the control group (non-surgical) included in the study. The study analysed self‐reported weight‐loss methods and weight changes over ten years and found that 83 percent were constantly striving to lose weight or prevent weight gain.

Abnormal lipid metabolism predicts weight gain and T2DM in women

The inefficient breakdown of fats predicts later weight gain and metabolic complications such as type 2 diabetes in women, according to researchers from the Karolinska Institutet. Low levels of hormone-stimulated lipolysis - a biochemical process by which triglycerides are broken down into energy-rich fatty acids - were associated with weight gain and metabolic problems 13 years later. Based on the findings, the researchers developed an algorithm to detect impairments in hormone-stimulated lipolysis using clinical and blood measures.

Chronic stress-hormone pulses controls weight gain

A study by Stanford University School of Medicine researchers has provided the first molecular understanding of why people gain weight due to chronic stress, disrupted circadian rhythms and treatment with glucocorticoid drugs. According to the researchers, it is related to the timing of the dips and rises of a class of hormones called glucocorticoids - predominantly the stress hormone cortisol - according to a new study by Stanford University School of Medicine researchers.

Serotonin associated with weight gain and calorie control

Serotonin play a significant role in the body's weight gain and calorie control, according to researchers from Flinders University, SAHMRI and the University of Adelaide. It has been known for years that serotonin is a contributor to feelings of happiness and sadness however, this latest study has reported that elevated concentrations of serotonin, the crucial neurotransmitter that chemically transmits messages to nerve cells in the body, is also linked to obesity, and the researcher stated that more research into serotonin could reduce obesity rates.

Dietary fibre protects against obesity and metabolic syndrome

Consumption of dietary fibre can prevent obesity, metabolic syndrome and adverse changes in the intestine by promoting growth of ‘good’ bacteria in the colon, according to a study led by Georgia State University. The researchers found enriching the diet of mice with the fermentable fibre inulin prevented metabolic syndrome that is induced by a high-fat diet, and they identified specifically how this occurs in the body.

Weight changes alters molecular microbiome and gene expression

The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine. They found that as people gain or lose excess weight they exhibit notable changes in their microbiome, cardiovascular system, immune system and levels of gene expression.

Fat shaming can be mentally and physically harmful

Medical discrimination based on people's size and negative stereotypes of overweight people can take a toll on people's physical health and well-being, according to a review of recent research presented at the 125th Annual Convention of the American Psychological Association.

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