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Insights into gender differences in diabetes and aging

Researchers at the Buck Institute provided a possible answer to why overweight men are more prone to get type 2 diabetes than are overweight women, by discovering that a protein involved in nutrient sensing and metabolism gets inhibited in male - but not female - mice fed a high fat diet. In addition to providing a pathway to deal with the gender difference, the findings, published in Cell Reports, also show that boosting the protein protects male mice from age-induced obesity and metabolic decline.

Bariatric surgery appears to reverse premature aging

Weight loss from bariatric surgery appears to reverse the premature aging associated with obesity, according to research presented at Frontiers in CardioVascular Biology (FCVB) 2016. In his presentation, ‘Reversal of premature aging markers after bariatric surgery', Dr Philipp Hohensinner, a researcher at the Medical University of Vienna in Vienna, Austria, said that surgical patients had longer telomeres and less inflammation two years after surgery.

Rapamycin causes older rats to lose weight

A group of University of Florida Health researchers has discovered that an existing drug reduces body fat and appetite in older rats, which has intriguing implications for aging humans. Rapamycin, a pharmaceutical used to coat coronary stents and prevent transplant rejection, reduces obesity and preserves lean body mass when given intermittently to older rats.

Bariatric surgery may turn back the effects of aging

Surgical weight loss may turn back the effects of aging at a genetic level, according to researchers from Stanford University. Researchers discovered after gastric bypass, certain patients' telomeres actually became longer. Preoperative patients with high levels of LDL cholesterol, and high levels of inflammation (CRP), not only saw these levels drop within a year of surgery, they also experienced significant lengthening of their telomeres, when compared to patients with initial low LDL and CRP levels.

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