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News about clinical research: trials, studies, case reports, etc.

App predicts risk of developing hernia following abdominal surgery

A new app can predict the likelihood that a patient will develop an incisional hernia following abdominal surgery, using data to potentially help address a problem effects one out of every eight of these surgical patients. Researchers at the Perelman School of Medicine at the University of Pennsylvania developed the app utilising electronic health records (EHR) to identify the most common risk factors for patients, as well as which surgeries most commonly result in incisional hernias across multiple specialties, they validated the app based on data from almost 30,000 patients.

How epigenetics impacts obesity and type 2 diabetes

In the past decade, knowledge of how lifestyle affects our genes (epigenetics) has grown exponentially. Researchers at Lund University have summarised the state of scientific knowledge within epigenetics linked to obesity and type 2 diabetes in a review article published in the scientific journal Cell Metabolism.

Obesity associated with differences in form and structure of the brain

Researchers using sophisticated MRI technology have found that higher levels of body fat are associated with differences in the brain's form and structure, including smaller volumes of grey matter, according to a study published in the journal Radiology. The findings add important information to our understanding of the connection between obesity and negative health consequences such as dementia.

Metformin may help patients maintain weight loss long-term

In the Diabetes Prevention Program (DPP) clinical trial and its long-term follow-up study, among the persons who lost at least 5 percent of their body weight during the first year, long-term maintenance of weight loss was more likely if they had been assigned to treatment with metformin than with placebo or lifestyle intervention. Being older and losing a greater amount of weight in the first year were the most consistent predictors of lasting weight loss.

No increase in complications with abdominoplasty in patients with obesity

Abdominoplasty can be safely performed in obese patients, with no increase in complications compared to non-obese patients, according to researchers from Long Island Plastic Surgical Group, Garden City, NY, USA. In this study, the authors compare the outcomes of obese and nonobese patients who underwent abdominoplasty. The findings help to alleviate concerns that patients with obesity are at higher risk of complications after abdominoplasty.

Revita DMR can benefit both NAFLD, NASH and type 2 diabetes

Fractyl Laboratories has announced new clinical data showing its same-day therapeutic procedure - Revita Duodenal Mucosal Resurfacing (DMR) procedure - can generate significant improvements in both nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and type 2 diabetes (T2DM) in people with both conditions. The data was presented at The International Liver Congress, the EASL annual meeting, in Vienna, Austria.

Rheumatic disorders improved post-op risk of fractures increased

A literature review by researchers looking at the complex relationship between obesity, various rheumatic diseases and bariatric surgery has underscored the need to establish long-term prospective controlled trials evaluate the risk-benefit ratio of bariatric surgery in patients with morbid obesity and rheumatic diseases.

Cognitive functioning not a predictor of weight-loss for adolescents

Young people with cognitive impairments and developmental disabilities (CI/DD), including Down syndrome, have similar weight-loss trajectories to those with typical cognitive function after bariatric surgery, according to a study by psychologists at Children's National Health System, Washington DC.

Kuwait publishes 1st National Bariatric Registry Report

The State of Kuwait Ministry of Health and Dendrite Clinical Systems, in conjunction with Bader Sultan & Brothers Company, are delighted to announce the publication of the First Kuwait National Bariatric Registry Report 2019, the first ever national report on bariatric and metabolic surgery in the Arabian Gulf region. This inaugural report, which includes 3,302 bariatric surgery cases, contains data on baseline obesity-related disease, operation types, operative outcomes and disease status after bariatric surgery in Kuwait.

RYGB offers better weight loss but higher readmission rates vs LSG

One-year outcomes from over 47,000 Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy procedures has reported that RYGB resulted in a higher rate of patients with total weight loss (TWL) >20% (95.8% vs 84.6%, p<0.001). However, there were no significant differences between the two procedures in the rate of severe complications (2.6% vs 2.4%, p=0.382) and 30-day mortality (0.04% vs 0.03%, p=0.821), although readmission rates were higher post-RYGB (4.3% vs 3.4%, p<0.001).

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