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News about clinical research: trials, studies, case reports, etc.

New reports provide guidance for obesity care

Advocates for obesity prevention and treatment have designed two new resources for medical educators, healthcare providers and community programmes that will enhance the level of care for patients, according to two new studies published in Obesity, the journal of The Obesity Society. The resources include the first set of competencies for how to care for patients with obesity for undergraduate and graduate medical education, and a proposed standard of care for people with obesity.

New mutation in leptin gene may explain excess of body fat

Researchers at Texas Biomedical Research Institute, San Antonio, TX, have discovered a new mutation in the gene that regulates the key hormone suppressing hunger called leptin. This new mutation could help researchers understand why people develop excess of body fat. The research is aimed at helping tackle metabolic disorders like cardiovascular disease and diabetes which are fuelled by obesity and impact millions of people around the world.

Plasma leptin concentrations are not limited to the brain

Yale researchers have offered insight into leptin - a hormone that plays a key role in appetite, overeating and obesity - heir findings advance knowledge about leptin and weight gain, and also suggest a potential strategy for developing future weight-loss treatments, they said.

UAE Obesity Conference – it’s time to act upon obesity

On behalf of the organising committee of the UAE Obesity Conference (UOC) it is my privilege and great pleasure to invite you to the UOC "It’s time to act upon obesity"  18-19 October 2019 Abu Dhabi, UAE (

The conference is a combined effort between Healthpoint Hospital, ICLDC, SKMC, Al Ain Hospital, CCAD and Mohammed Bin Rashid University stakeholders. The scientific committee has put together two days of scientific content delivered by medical, allied health and surgical health experts.

Prophylactic IVC filters pre-surgery associated with worse outcomes

Prophylactic inferior vena cava filters (IVCFs) implantation prior to bariatric surgery was associated with worse clinical outcomes and increased health care resource utilisation, according to researchers from the Temple University. The role of implanting prophylactic IVCFs prior to bariatric surgery is controversial and the clinical outcomes/benefits associated with this practice are unknown.

Oral semaglutide shows CV safety in T2DM patients

Novo Nordisk has announced that the PIONEER 6 trial achieved its primary endpoint by demonstrating non-inferiority of major adverse cardiovascular events (MACE) with oral semaglutide compared with placebo, both in addition to standard of care. PIONEER 6 was an event-driven, pre-approval cardiovascular outcomes trial for oral semaglutide. It was a randomised, double-blinded, placebo-controlled trial evaluating the cardiovascular safety of oral semaglutide vs placebo when added to standard of care in 3,183 people with type 2 diabetes at high risk of cardiovascular events.

Henry Buchwald receives ACS Jacobson Innovation Award 2019

The 2019 Jacobson Innovation Award of the American College of Surgeons (ACS) was presented to Dr Henry Buchwald, at a dinner held in his honour, by ACS President, Dr Ronald V Maier, for his life-long pioneering work and innovative research. The prestigious Jacobson Innovation Award honors living surgeons who have been innovators of a new development or technique in any field of surgery and is made possible through a gift from Dr Julius H Jacobson II, and his wife Joan.

People of a higher weight status more likely to binge eat

Binge eating is prevalent across socioeconomic status (SES) groups in the US and is linked to depressed mood, anxiety and obesity. A new study led by the University of Minnesota School of Public Health, explore the impact of several risk factors for binge eating among youth from different socioeconomic groups has reported that those at higher weight status were 3.2 times as likely to binge eat as those of healthy weight.

Using microRNA to detect early signs of type 2 diabetes in teens

Researchers know that exosomes, tiny nanoparticles released from fat cells, travel through the bloodstream and body, regulating a variety of processes, from growth and development to metabolism. The exosomes are important in lean, healthy individuals in maintaining homeostasis, but when fat gets 'sick' - the most common reason for this is too much weight gain - it can change its phenotype, becoming inflammatory, and disrupts how our organs function, from how our skeletal muscle and liver metabolise sugar to how our blood vessels process cholesterol.

Invokana reduces MACE and kidney failure in T2DM patients

The results of a new subgroup analysis from the landmark Phase III CREDENCE study shows Invokana (canagliflozin) significantly reduced the risk of major cardiovascular (CV) events and kidney failure in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in patients with and without known cardiovascular (CV) disease. The results were presented at the American Diabetes Association’s 79th Scientific Sessions in San Francisco.

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