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News about clinical research: trials, studies, case reports, etc.

Weight gain in early adult life associated with risk of premature death

Gaining weight from your mid-20s into middle age is associated with an increased risk of premature death, according to a study of US adults by researchers from Huazhong University of Science and Technology, Wuhan, China. Weight loss at older ages (from middle to late adulthood) was also linked to higher risk and the findings highlight the importance of maintaining normal weight throughout adult life to reduce the risk of premature death, the researchers explained.

Gastric bypass reduces risk of birth defects

Children born to women who underwent gastric bypass surgery before becoming pregnant had a lower risk of major birth defects than children born to women with severe obesity at the start of their pregnancy, according to a matched cohort study by researchers at Karolinska Institutet and Örebro University, Sweden.

Cancer risk increases for individuals who are overweight before 40

The risk of cancer increases considerably if a person gains weight before the age of 40 with the risk of endometrial cancer increasing by 70 percent, according to an international study, headed by researchers from University of Bergen, Norway.

“Obesity is an established risk factor for several cancers,” said Professor Tone Bjørge, University of Bergen. “In this study, we have focused on the degree, timing and duration of overweight and obesity in relation to cancer risk.”

Sleeveballoon mimics the effects of bariatric surgery in rodents

A newly-tested medical device, called Sleeveballoon, mimics the effects of traditional bariatric surgery in rodents and produces impressive results on body weight, fatty liver and diabetes control, according to researchers from King's College London, UK. The Sleeveballoon is a device that combines a balloon with a connected sleeve, which covers the initial parts of the small intestine. It is inserted into the stomach and bowel during minimally invasive surgery under general anaesthetic.

Efficacy of concomitant hiatal hernia repair and TIF 2.0 for GERD

EndoGastric Solutions has announced the publication of clinical data confirming that concomitantly performed hiatal hernia (HH) repair and the Transoral Incisionless Fundoplication (TIF 2.0) procedure using the EsophyX device, is an effective treatment for patients with a HH larger than 2cm contributing to their gastroesophageal reflux disease (GERD).

Biliopancreatic diversion improves insulin sensitivity vs RYGB

Some studies have demonstrated that biliopancreatic diversion has been better at reducing diabetes compared to Roux-en-Y gastric bypass, because it typically causes greater weight loss. However, small study by researchers at Washington University School of Medicine in St Louis have reported that biliopancreatic diversion appears to be more effective at eliminating diabetes not just because of greater weight loss but because the procedure itself seems to make patients more sensitive to insulin.

Abdominoplasty improves quality of life despite risk of complications

Abdominoplasty has a high patient satisfaction and improved the quality of life in patients who are overweight or have obesity despite a substantial risk of complications, according to a study published in Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

An ‘overwhelming majority’ of overweight/obese patients are happy with the results of abdominoplasty, according to the study by Dr Dennis C Hammond and colleagues of Partners in Plastic Surgery of West Michigan, Grand Rapids.

Strong association between obesity and chronic diarrhoea

In the most comprehensive analysis of the relationship between body mass index (BMI) and bowel habits to date, published in Alimentary Pharmacology & Therapeutics, a team of physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) found a strong association between obesity and chronic diarrhoea independent of an individual's dietary, lifestyle, psychological factors or medical conditions. The findings could have important implications for how physicians might approach and treat symptoms of diarrhoea in patients with obesity.

Treating adolescent obesity - the evidence behind the options

As rates of adolescent obesity continue to rise, choice of treatment needs to be guided by the severity of obesity, psychosocial factors, comorbidities and patient's age and pubertal status, according to a paper published in the Journal of the American Medical Association.

Increase in psychiatric illness presentations after bariatric surgery

Researchers from Australia have reported an increase in mental health service presentations after bariatric surgery, particularly among those who had prior psychiatric illnesses or developed surgical complications requiring further surgery.

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