This week we report on papers from the journal Diabetes Care, the American Journal of Physiology - Endocrinology and Metabolism, Endoscopy, Radiology Medicine and the International Journal of Obesity.
A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass.
Reporting in the journal, Diabetes care, researchers from the Geisinger Clinic, Danville, Pennsylvania examined the roles fibroblast growth factor 19-BA pathway plays a role in the remission of human diabetes after RYGB surgery. Circulating FGF19 and bile acids levels, hepatic glycogen content, and expression levels of genes regulating the FGF19-BA pathway were compared among these groups of patients using pre- and postoperative serum samples and intraoperative liver biopsies. The results showed that preoperatively, patients with diabetes had lower FGF19 and higher BA levels than nondiabetic patients, irrespective of body weight. In diabetic patients undergoing RYGB, lower FGF19 levels were significantly correlated with increased hepatic expression of the cholesterol 7alpha-hydroxylase 1 (CYP7A1) gene, which modulates BA production. (Abstract)
Effects of Sleeve Gastrectomy and Ileal Transposition, Alone and in Combination, on Food Intake, Body Weight, Gut Hormones, and Glucose metabolism in Rats.
Writing in the American Journal of Physiology - Endocrinology and Metabolism, investigators from the University of Calgary, Canada, compared the effects of a sleeve gastrectomy, with ileal transposition alone and together sleeve or sham manipulations, on food intake, body weight, gut hormones, glucose tolerance and key markers of glucose homeostasis in peripheral tissues of adult male Sprague Dawley rats (450-550g; n=7-9/group). The results suggested that enhanced lower gut stimulation following the three procedures leads to transient reduction in food intake and weight gain together with enhanced secretion of lower gut hormones and improved glucose clearance by peripheral tissues. (Abstract)
Evaluation of an endoscopic suturing device for transoral outlet reduction in patients with weight regain following Roux-en-Y gastric bypass.