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Race, obesity and prostate cancer

Obese African-American men face prostate cancer risk

Obesity in black men substantially increases the risk of low- and high-grade prostate cancer

Obesity has a profoundly different effect on prostate cancer risk in African-American as compared to non-Hispanic white men, according to a study 'Difference in Association of Obesity With Prostate Cancer Risk Between US African American and Non-Hispanic White Men in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)' published in JAMA Oncology. The paper reports that obesity in black men substantially increases the risk of low- and high-grade prostate cancer, while obesity in white men moderately reduces the risk of low-grade cancer and only slightly increases the risk of high-grade cancer.

The findings are based on data collected during the Selenium and Vitamin E Cancer Prevention Trial (SELECT), an international clinical trial that tested whether supplemental selenium and/or vitamin E could prevent prostate cancer, and led by researchers at Fred Hutchinson Cancer Research Center and the University of Washington.

The research team, led by senior author Dr Alan Kristal, a member of the Fred Hutch Public Health Sciences Division, and first and corresponding author, Dr Wendy Barrington, an affiliate public health investigator at Fred Hutch and an assistant professor at the University of Washington School of Nursing, found that black men who are obese had a 122 percent increased risk of low-grade and an 81 percent increased risk of high-grade prostate cancer, compared to those who were of normal weight. In contrast, among non-Hispanic white men, those who were obese had a 20 percent reduced risk of low-grade and only a 33 percent increased risk of high-grade prostate cancer compared to those of normal weight.

"For unknown reasons, African-American men have a much higher risk of prostate cancer than non-Hispanic white men. Different effects of obesity might explain at least some of the difference in risk and, more importantly, preventing obesity in African-American men could substantially lower their prostate cancer risk," said Kristal.

According to the National Cancer Institute, black men have the highest prostate cancer rates of any racial or ethnic group in the US, they tend to get more aggressive forms of this cancer and are more than twice as likely to die of the disease as compared to non-Hispanic white men. These elevated risks for African-American men are due to both social disadvantage, such as access to resources, as well as biologic factors.

This study suggests obesity may play an important role behind what Kristal and Barrington call the "African-American race effect" on disparities in prostate cancer risk.

"Given that obesity is more common among African-Americans, [the prostate cancer-obesity connection] is an important question to study, as it may shed light on how to reduce black/white disparities in prostate cancer incidence," she said.

More than 35,000 men from across the US, Canada and Puerto Rico were followed carefully for the development of cancer and other diseases, and a single study pathologist examined prostate tissue from the men diagnosed with prostate cancer to determine whether it was low- or high-grade disease. The trial ended early, because after an average of five years there was no evidence that either of the supplements lowered prostate cancer risk. The study did, however, provide a treasure trove of high-quality data on risk factors such as race, height, weight and family history, as well as the use of prostate-cancer screening.

The obesity finding was "serendipitous" and "potentially of enormous importance," added Kristal.

"In an unrelated analysis we wanted to statistically control for effects of obesity. We noticed that the associations of obesity with prostate cancer risk in African-American men were very different than those for non-Hispanic white men,” she explained. "There is some evidence that the biological responses to obesity, such as inflammation and glucose tolerance, are more pronounced in African-American men; both inflammation and insulin may promote cancer development. Obesity might also have an impact on genes that control prostate cancer growth, but frankly this is just speculation. This is the next question for researchers to ask, because the answer will likely tell something very important about prostate cancer development and prevention."

While the study's findings concerning obesity and prostate cancer risk in black men are novel and need to be replicated, they underline the ongoing public health toll of the obesity epidemic.

"Obesity prevention and treatment should be a priority for all Americans, but in particular for African-American men," said Barrington. "Prostate cancer kills 45 out of 100,000 African-Americans and only 19 out of 100,000 white men, and obesity is contributing to this important health disparity. Health care providers need to consider obesity prevention for their African-American male patients as a targeted strategy to reduce prostate cancer disparities."

To access this paper, please click here

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