Most recent update: Friday, October 20, 2017 - 14:37

Bariatric News - Cookies & privacy policy

You are here

GLP-1 post-RYGB

Increased secretion and action of GLP-1 post-RYGB

Increased role of GLP-1 in the insulin response following gastric bypass

The increased secretion and action of GLP-1 after gastric bypass surgery is not entirely due to rapid passage of nutrients into the lower gut, according to a a single case study by investigators from University of Cincinnati (UC).  The study appears on in the journal Diabetologia.

"In patients with severe hypoglycaemia, gastric bypass reversal is a consideration," said Dr Marzieh Salehi,  associate professor in the division of endocrinology, metabolism and diabetes. “But our new findings show that simply reversing gastric bypass several years after surgery may not reverse the hormonal effects brought on by the surgery itself, namely a new 'cross-talk' between gut and pancreas."

Marzieh Salehi

The investigators compared glucose metabolism in an eight-year post-surgery gastric bypass patient, with an existing gastric feeding tube due to other medical reasons, to a group of healthy controls.

Uniquely, the patient could ingest nutrients both orally and via the gastric feeding tube (going through or bypassing foregut, a re-routed stomach pouch attached to the small intestine), allowing researchers to test whether the actual route of meal ingestion made a difference when it came to how the participant's body metabolized glucose.

While it is commonly agreed that weight loss-independent effects of gastric bypass on glucose metabolism are due to the enhanced secretion, and action, of one of the gut hormones, GLP-1, the question remained as to whether this increase is due to the rapid transit of nutrients through the reconfigured gastrointestinal tract.

They reported that the patient had increased plasma GLP-1 concentrations and GLP-1 action independent of the route of feeding compared to healthy controls.

“It is likely that the increased secretion and action of GLP-1 after gastric bypass surgery is not entirely due to rapid passage of nutrients into the lower gut,” said Salehi. "Understanding the underlying mechanisms by which gastric bypass improves blood sugar levels will guide the development of therapeutic options, as GLP-1 based drugs have been utilized for treatment of diabetes over the last decade.”

Although these findings pertain to a single-person case study, they researchers said that they are in keeping with previous results that indicated an increased role of GLP-1 in the insulin response following gastric bypass.

Want more stories like this? Subscribe to Bariatric News!

Bariatric News
Keep up to date! Get the latest news in your inbox.