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Study reveals new insights into weight gain and T2DM
Strategies that concentrate on small weight reductions may be more beneficial than predominantly focusing on weight loss for high-risk individuals, according to research published in PLOS Medicine. Although it is a common notion that type 2 diabetes is precipitated by substantial progressive weight gain, this latest study suggests that this might not be true.
Investigators Dorte Vistisen and Kristine Færch, from the Steno Diabetes Center in Gentofte, Denmark, and colleagues analysed data from participants of the Whitehall II cohort, a group of London-based civil servants who have been followed for more than a decade, to see what changes in body weight and other parameters had occurred in people in the years before they were diagnosed with diabetes.
The results revealed that three patterns of obesity changes prior to diabetes diagnosis were accompanied by distinct trajectories of insulin resistance and other cardiometabolic risk factors in this white, British population. While these results should be verified independently, the great majority of patients had modest weight gain prior to diagnosis.
A total of 6,705 participants were free of diabetes when they entered the study and were tested for diabetes every five years, and 645 of them were subsequently diagnosed with the disease. Going back to measurements of BMI which were recorded regularly, the researchers used a statistical method to identify patterns of change in BMI among individuals who went on to develop diabetes.
They identified three groups: by far the largest (comprising 606 individuals) were "stably overweight," and showed little change in their BMI over the years before they were diagnosed with diabetes. A second, much smaller group (15 participants) had gained weight continuously in the years before diagnosis. The remaining 26 participants were persistently obese for the entire time they participated in the study, in some cases for 18 years before they developed diabetes.
Because the three distinct patterns of obesity development were accompanied by different changes over time in insulin resistance and other risk factors for heart disease and diabetes, the authors concluded that "type 2 diabetes is a not a single disease entity, but rather a heterogeneous disease with different pathophysiological pathways depending on the level and development of obesity."
The researchers believe that this study is the first to apply this methodology to the question of how weight changes relate to the development of diabetes, and it used data from a homogeneous group of all-white civil servants. Before drawing firm conclusions on the process of diabetes development, it will be important to confirm the results in additional and more diverse populations.
“The results are provocative and should stimulate debate on how best to identify people at risk for diabetes and how to prevent the disease or delay its onset,” the authors comment. “Strategies focusing on small weight reductions for the entire population may be more beneficial than predominantly focusing on weight loss for high-risk individuals."
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