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Journal Watch 20/01/2014

This week we report on papers from the Journal of Hepatology, the American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology, the Journal of Laparoendoscopic & Advanced Surgical Techniques, the Journal of Diabetes and the International Journal of Surgery Case Reports…

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients.

Published in the Journal of Hepatology, the study investigated the effects of bariatric surgery on hepatic insulin sensitivity. Twenty-three morbidly obese (nine diabetic and fourteen non-diabetic) patients and ten healthy, lean control subjects were studied using PET to assess hepatic glucose uptake in the fasting state and during euglycaemic hyperinsulinemia. Obese patients were studied before bariatric surgery (either sleeve gastrectomy or Roux-en-Y gastric bypass) and six months after surgery. The researchers concluded that  surgery leads to a significant improvement in hepatic insulin sensitivity: as insulin-stimulated hepatic glucose uptake was improved and endogenous glucose production reduced when measured, six-months, after surgery. Abstract

GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents.

Featured in the American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology, the researchers examined complementary pharmacological and genetic loss-of-function approaches to test the role of increased signalling of GLP-1 and PYY in high-fat diet-induced obese rodents. The reported that there was no evidence that either gut hormone an important role in the specific mechanisms by which RYGB rats settle at a lower body weight. They state that the beneficial effects of bariatric surgeries are expressed through complex mechanisms that require combination approaches for their identification. Abstract

Single-Incision Laparoscopic Sleeve Gastrectomy Versus Multiport Laparoscopic Sleeve Gastrectomy: Analysis of 80 Cases in a Single Center.

Writing in the Journal of Laparoendoscopic & Advanced Surgical Techniques, researchers examined the role of single-incision laparoscopic sleeve gastrectomy (SILS-G) in 40 morbidly obese patients. They concluded that SILS-G is a feasible and safe operative procedure that leads to a significant reduction of total operative time compared with a multiport access procedure. However, they acknowledge that further potential benefits associated with single-incision laparoscopic surgery remain to be investigated objectively. Abstract

Statistical Models to Predict Type 2 Diabetes Remission After Bariatric Surgery.

Reporting in the Journal of Diabetes, investigators evaluated the relevance of several preoperative factors and developed statistical models to predict T2D remission one year after bariatric surgery. They retrospectively studied 141 patients (57.4% women), with a preoperative diagnosis of T2D, who underwent BS in a single centre (2006-2011). They concluded that preoperative characteristics determine T2D remission rates after BS to different extents and that the use of statistical models may help clinicians reliably predict T2D remission rates after BS. Abstract

Laparoscopic sleeve gastrectomy with loop bipartition: A novel metabolic operation in treating obese type II diabetes mellitus.

Published in the International Journal of Surgery Case Reports, researchers report the first case of laparoscopic sleeve gastrectomy with loop bipartition (a modified form of Santoro's operation) in the treatment of type II diabetes mellitus associated with obesity. They conclude that a sleeve gastrectomy with loop bipartition may be a very effective and simple operation to treat uncontrolled diabetes associated with obesity with a lot of apparent advantages over most current metabolic procedures available at the moment. Abstract