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Obesity and migraine

Patients with obesity can decrease frequency of migraines by losing weight

(Source: SashaW)
Weight loss was linked with significant reductions in headache frequency, pain intensity and disability (all p<0.0001), as well as attack duration (p=0.01)

For migraine sufferers with obesity, losing weight can decrease headaches and improve quality of life, according to researchers from Italy and the United States. The results of their meta-analysis, ‘SAT-108. Effects of Bariatric and Non-Bariatric Weight Loss on Migraine Headache in Obesity. A Systematic Review and Meta-Analysis’, were presented at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, LA.

"If you suffer from migraine headaches and are obese, losing weight will ameliorate the quality of your family and social life as well as your work and school productivity,” said lead study author. Dr Claudio Pagano, an associate professor of internal medicine at the University of Padova in Padova, Italy.” Your overall quality of life will greatly improve. Weight loss in adults and children with obesity greatly improves migraine headache by improving all the main features that worsen migraineurs' quality of life. When people lose weight, the number of days per month with migraine decreases, as does pain severity and headache attack duration."

To investigate the effects of weight loss achieved through bariatric surgery or behavioural intervention on migraine frequency and severity, Pagano and his colleagues reviewed the standard online medical research databases for studies that considered pain intensity, headache frequency, attack duration, disability; and BMI, BMI change, intervention (bariatric surgery versus behavioural), and population (adult versus paediatric).

In a meta-analysis of the 473 patients in the ten studies that met the researchers' inclusion criteria, they found that weight loss was linked with significant reductions in headache frequency, pain intensity and disability (all p<0.0001), as well as attack duration (p=0.01).

Migraine improvement was not linked with either degree of obesity at baseline or amount of weight reduction. Also, the effect on migraine was similar when weight reduction was achieved through bariatric surgery or behavioural intervention and was comparable in adults and children.

"Weight loss reduces the impact of conditions associated with obesity, including diabetes, hypertension, coronary heart disease, stroke and respiratory diseases," said Pagano. "Obesity and migraine are common in industrialized countries. Improving quality of life and disability for these patients will greatly impact these populations and reduce direct and indirect healthcare costs."

The mechanisms linking obesity, weight loss and migraine headache remain unclear, according to the authors, but they may include alterations in chronic inflammation, adipocytokines, obesity comorbidities, and behavioural and psychological risk factors.

Moderators and meta-regression analysis showed that improvement in migraine was not correlated either to the degree of obesity at baseline or the degree of weight reduction. In addition, the effect on migraine was similar when weight reduction was obtained with bariatric surgery or behavioural intervention and was comparable in adult and paediatric populations.

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