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Post-bariatric surgery hypoglycaemia

Glucagon delivery system reduces episodes of post-op hypoglycaemia

Currently, the research team is conducting a randomised, double-blind placebo-controlled trial of this system, which aims to show whether the closed loop system can prevent hypoglycaemia

A new ‘smart’ glucagon delivery system created by researchers from the Joslin Diabetes Center and Harvard School of Engineering and Applied Sciences may make it possible for people with post-bariatric hypoglycaemia to live free from this dangerous complication. Current treatments for post-bariatric hypoglycaemia, including a special diet and medications, have their limitations. The findings from this latest are important because the number of bariatric surgeries is going up and physicians do not have adequate tools to treat this condition. In recent years, however, a number of innovative advances have opened the door to a new approach. The research, ‘Design and Clinical Evaluation of a Novel Low-Glucose Prediction Algorithm with Mini-Dose Stable Glucagon Delivery in Post-Bariatric Hypoglycemia, Diabetes Technology & Therapeutics’, appears in the journal Diabetes Technology & Therapeutics.

Mary-Elizabeth Patti (Credit: John Soares)

"One potential way to treat this complication is to use glucagon, a natural hormone made by the body that raises glucose. It is used to treat severe hypoglycaemia in patients with diabetes,” said study senior author, Dr Mary-Elizabeth Patti, Co-Director of the Advanced Genetics and Genomics Core, Director of the Hypoglycaemia Clinic, and Assistant Professor of Medicine at Harvard Medical School. “If we give someone glucagon right before they became hypoglycaemic we might be able to prevent hypoglycaemia. Essentially, we are combining three new developments into one system that is being used to both prevent and treat hypoglycaemia.”

The components of this novel system include a continuous glucose monitor (CGM), which is a sensor that checks glucose values every five minutes; an investigational form of glucagon that can be delivered rapidly and precisely through a pump; and a mobile platform (pAPS) that hosts a novel hypoglycaemia prediction algorithm developed by the research team from Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) directed by Dr Eyal Dassau, senior author of the paper.

"The algorithm predicts when a hypoglycemic episode is about to occur and sets off alerts and can automate glucagon delivery," said co-author, Dr Alejandro J Laguna Sanz from the Harvard team.

In this preliminary study, the research team tested the system on seven participants diagnosed with post-bariatric hypoglycaemia. After the delivery system was placed on the participants, they were given a high carbohydrate liquid meal to induce severe hypoglycaemia and were then monitored for many hours. Investigators used what is called an open system. It beeped when participants were at high risk for hypoglycaemia. At that point, an investigator would administer a dose of glucagon.

"This system delivers small, precise doses of stable glucagon, which reverses but does not over-treat episodes of hypoglycaemia ," said study, Dr co-author Christopher Mulla, Staff Endocrinologist and Postdoctoral Research Fellow at the Joslin Diabetes Center.

Over the course of the study, progressive changes were made to the computer algorithm and the glucagon dosage in order to fine tune the approach. Corrections were made by using earlier hypoglycaemia alarms or larger glucagon doses.

"This is a perfect example of medically-inspired engineering where a team from SEAS is partnering with a clinical team to resolve a major clinical need," said Dassau.

The single-dose glucagon used in the study was well-tolerated. It raised serum glucagon yet did not provoke increased insulin. This prediction system successfully alerted investigators to impending hypoglycaemia, and as the algorithm was refined throughout the study, the amount of time participants experienced hypoglycaemia decreased significantly.

"This will provide a new treatment for patients who typically have difficulty recognizing low blood sugars," added Mulla. "Many of these patients can have hypoglycaemia unawareness, which means that they don't know their blood glucose is dropping. Consequently, they can become incapacitated and have difficulty treating themselves once they do recognize that they are not feeling well."

While this study tested an open loop system, meaning the investigators had to activate the delivery of the medicine, it has cleared the way for future studies where the closed loop system (the computer algorithm collects the data, detects hypoglycaemia, and tells the pump to deliver glucagon) can be used.

Currently, the research team is conducting a randomised, double-blind placebo-controlled trial of this system, which aims to show whether the closed loop system can prevent hypoglycaemia.

"The system that we are testing now is the one we hope to use in patients as an outpatient treatment," added Patti.

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