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Healthier fat storage

Aerobic exercise may lead to healthier fat storage

Researchers also found indications that the regular exercisers had more blood vessels in their fat tissue than non-exercisers

Researchers from the University of Michigan have identified key characteristics in fat tissue that may allow some obese adults to store their body fat more healthily and suggests that aerobic exercise may lead to healthier fat storage. Obese people who break down fat at a high rate are less healthy than their lean peers who store their fat more effectively, this is because when fat breaks down, many of the fatty acids released from the adipose tissue can take up residence elsewhere. Too much of this and fat can accumulate to harmful levels in other tissues and organs, which can fuel insulin resistance, a hallmark of type 2 diabetes and heart disease.

Most obese people develop insulin resistance, which can lead to type 2 diabetes and other chronic diseases. However, the researchers found that about one-third of the 30 obese adults in their study did not develop insulin resistance.

"It sounds counterintuitive, but if we can better understand how to store fat more effectively, and why some people are better at this than others, perhaps we can design therapies and preventions that will improve some of these obesity-related metabolic conditions," said principal investigator Jeffrey Horowitz, professor of movement science at the UM School of Kinesiology.

In one study, adipose tissue samples revealed that the healthier group broke down fat at slower rates and they had fewer proteins involved in fat breakdown and more involved in fat-storing. They also had fewer fibrotic cells in the adipose tissue, which allows tissue to be more flexible, and lower activation of certain inflammatory pathways.

In a second study, researchers collected fat tissue after a session of aerobic exercise from two groups of overweight people: one group exercised regularly, and the other group didn't. For both groups, just one session of exercise triggered signals that led to the growth of new blood vessels in fat tissue.

Researchers also found indications that the regular exercisers had more blood vessels in their fat tissue than non-exercisers. That's important because the health of most tissues hinges, in large part, on blood flow and nutrients, Horowitz said. When we gain weight, our fat cells expand, but if blood flow to fat tissue doesn't increase in parallel, it could become unhealthy or even necrotic.

Horowitz stressed that the two studies are relevant mainly to obese people at risk for metabolic disease. However, there's a takeaway here for everyone.

"We believe that the regular exercise we do now may create a healthier fat-storing environment for those times when we do overeat and gain weight," he added.

Taken together, the studies also support the notion that clinicians must redefine their view of fat

"Adipose tissue is scorned because most people see it as causing disease and obesity, but in general adipose tissue doesn't cause people to gain weight and become obese, it's just where we store our extra energy when we do overeat," Horowitz concluded. "Our studies aren't suggesting it is healthy to be obese or to overeat—but when we do overeat, it is important to have a safe place to store that extra energy. When people gain the same amount of body fat, those with adaptations to their fat tissue that can more healthfully accommodate the extra fat may be protected from developing insulin resistance and obesity-related diseases. We have identified some of these adaptations."

The two studies, ‘Factors regulating subcutaneous adipose tissue storage, fibrosis, and inflammation may underlie low fatty acid mobilization in insulin-sensitive obese adults’, and ‘Aerobic exercise elevates markers of angiogenesis and macrophage IL6 gene expression in the subcutaneous adipose tissue of overweight to obese adults’, were published in the Journal of Applied Physiology.

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