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Weight loss

Fasting glucose a marker for greater weight loss

Participants who had high fasting blood glucose lost a greater percentage of body weight (-9.4 percent) compared to those with low fasting blood glucose (-4.1 percent)

Researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, together with colleagues from Gelesis and the University of Copenhagen, Denmark, presented preliminary data demonstrating that study participants with high fasting plasma glucose lost more weight than those with low fasting plasma glucose when following a high-fibre, low-glycaemic load diet.

Presented at the American Diabetes Association's 77th Scientific Sessions, the data suggest that fasting plasma glucose levels could be helpful in determining the type of diet that is most effective for weight management for people with prediabetes or diabetes.

"Fasting blood sugar is easily measured and our findings suggest that it could serve as a useful measure in advising some patients on the type of diet that is most beneficial for their weight loss," said senior author, Dr Sai Krupa Das, scientist in the Energy Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston, MA. "The biggest benefits of the high-fibre, low-glycaemic diet were seen in people with high fasting blood sugar levels. Study participants with higher blood sugar levels lost more weight on a high-fibre, low-glycaemic diet than those on the same diet with lower blood sugar levels, suggesting that it might be possible to optimize weight loss approaches based on a simple clinical measure.”

Das is the senior author on the Healthy Weight for Living Study which found that workplace-based weight programmes could be an effective approach for people with significant weight loss goals. Data from that study was used in this new analysis.

Participants in the six-month study who were overweight or with obesity and who had high fasting blood glucose lost a greater percentage of body weight (-9.4 percent) compared to those with low fasting blood glucose (-4.1 percent). Notably, 79 percent of participants with high fasting blood glucose had lost five percent of their body weight compared to 50 percent with low fasting blood glucose.

In addition, 36 percent in the high group vs. 8 percent in the low group lost 10 percent of their body weight.

"The difference in response among those with high fasting blood sugar and lower fasting blood sugar is important. It might be time to consider glycemic status when advising patients on the best strategy for weight loss," said study author, Dr Susan B Roberts, director of the Energy Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

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