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Health improvements after RYGB

Health improvements after RYGB start before weight loss

Early Improvements in Blood Lipid Profile and Vascular Alterations after Gastric Bypass Surgery Prior to Dramatic Weight Loss

The health benefits of Roux-en Y gastric bypass (RYGB) surgery start soon after the procedure, according to research presented at the Experimental Biology 2016 meeting in San Diego. The study. ‘Early Improvements in Blood Lipid Profile and Vascular Alterations after Gastric Bypass Surgery Prior to Dramatic Weight Loss’, found that patients who underwent the procedure already showed some reductions in weight, waist circumference and body mass index one week after the procedure.

In the study, presented by Kristin Grogg, graduate student at West Virginia University's Center for Cardiovascular and Respiratory Sciences, the researchers evaluated the effect of weight reduction following laparoscopic RYGB on remodelling and improvements in arterial function, in addition to immediate reversal of metabolic deviations as weight is lost.

Patients that meet protocol inclusion criteria were invited to join the study during their one week preoperative clinical appointment. At this time, patients are consented and instructed to lie supine for ten minutes of quite relaxation. Patients then begin a sequence of non-invasive examinations, starting with a 12lead electrocardiogram, followed by an echocardiogram, carotid artery ultrasound, radial applanation tonometry and endothelial function analysis using EndoPAT technology. Upon completion of the non-invasive procedures a fasting blood sample is taken for analysis.

Preliminary findings show that RYGB results in significant body weight reduction (pre: 131.8±5.6 to post: 125±5.2kg) in morbidly obese subjects, along with reductions in BMI (pre: 45.2±2.3 to post: 42.9±2.2) and waist circumference (pre: 122.1±5.0 to post: 111.9±3.2cm) at the one week time point. Decrease in body size and weight was aided by a reduction in low density lipoprotein (pre: 127±6.2 to post: 113±4.5mg/dL), as well as suggested decreases in glucose levels. Such changes can be associated with an improvement of the lipid and glucose metabolism.

However, these results appear before subjects have lost a substantial amount of weight (one week postoperative), suggesting that noteworthy cardiovascular improvements post-RYGB are achieved prior to the hypothesized weight-related change. In addition, a number of improvements to the cardiovascular system were also marked at the one-week time point. Estimated left ventricular end systolic pressure and direct measure of left ventricular end systolic volume (pre: 66±4 to post: 55±3mmHg) declined post-surgery with an array of additional markers supporting alterations in central systolic blood pressure and myocardial oxygen demand.

The data suggest that vascular changes are happening in the early stages of recovery, prior to dramatic weight loss, thus suggesting vascular modifications are a result of an alternate surgical benefit.

"The data suggest that vascular changes are happening in the early stages of recovery, prior to dramatic weight loss, thus suggesting vascular modifications are a result of an alternate surgical benefit," the research team wrote. 

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